Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Serinc, an activity-regulated protein family, incorporates serine into membrane lipid synthesis.
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SERINC family expression facilitates serine-derived lipid synthesis.
"facilitates the synthesis of two serine-derived lipids, phosphatidylserine and sphingolipids."
SERINC3 and SERINC5 restrict HIV-1 infectivity and are counteracted by Nef.
HIV-1 Nef promotes infection by excluding SERINC5 from virion incorporation.
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SERINC3 is a weaker HIV-1 restriction factor than SERINC5.
"SERINC5, and to a lesser extent SERINC3, as a potent inhibitor of HIV-1 particle infectivity"
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.
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Purified human SERINC proteins flip PS, PE, and PC.
"purified hSERINCs reconstituted into proteoliposomes induce flipping of phosphatidylserine (PS), phosphatidylethanolamine and phosphatidylcholine."
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SERINC3-mediated lipid scrambling exposes viral phosphatidylserine and reduces infectivity.
"SERINC3, SERINC5 and the scramblase TMEM16F expose PS on the surface of HIV-1 and reduce infectivity"
SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane
Mechanism of Phosphatidylserine Lipid Scrambling by Human SERINC3, an HIV-1 Restriction Factor.
UniProtKB record for human SERINC3 (Q13530)
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Reviewed UniProt summarizes human SERINC3 scramblase, antiviral, topology, localization, and isoform evidence.
"Functions as a scramblase that flips"
Manual deep-research synthesis for human SERINC3
Manual SERINC3 curation notes