OAR1 (YKL055C, P35731) notes

• Mitochondrial NADPH-dependent 3-oxoacyl-ACP reductase (SDR family, EC 1.1.1.100) of mtFAS [UniProt:P35731 "Reaction=a (3R)-hydroxyacyl-[ACP] + NADP(+) = a 3-oxoacyl-[ACP] + NADPH"].
• Disruption gives respiratory deficiency PMID:9388293.
• NADPH-dependence and functional context PMID:19571038; human HSD17B8/CBR4 restore lipoic acid of oar1 null PMID:19571038.
• mtFAS product octanoyl-ACP -> lipoic acid PMID:19571038.
• YeastPathways places OAR1 in seven cytosolic FAS pathways (myristate, palmitate, stearate, elongation...) - the cytosolic KR step is the FAS2 KR domain; cytosol rows wrong.
• IBA quinone binding (from CBR4 node) - no evidence for Oar1.
• Aerobic respiration IMP: respiratory defect is a downstream consequence of loss of lipoylation/mtFAS products.