Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Combined Automated Annotation using Multiple IEA Methods
Homeoprotein DLX-1 interacts with Smad4 and blocks a signaling pathway from activin A in hematopoietic cells.
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DLX1 is expressed in hematopoietic cells in a lineage-dependent manner
"We report here that, in addition to the previously reported regions/cells, DLX1 is expressed in hematopoietic cells in a lineage-dependent manner"
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DLX1 interacts with Smad4 through its homeodomain
"DLX1 interacts with Smad4 through its homeodomain"
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DLX1 blocks multiple signals from TGF-beta superfamily cytokines
"We show that it blocks multiple signals from TGF-beta superfamily cytokines such as activin A, TGF-beta1, and BMP-4"
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DLX1 functions as a regulator of TGF-beta superfamily signals during blood production
"Taken together, these data suggest that DLX1 may function as a regulator of multiple signals from TGF-beta superfamily members in broad biological contexts during blood production"
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
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Systematic analysis of 542 human TFs using methylation-sensitive SELEX
"By analysis of 542 human TFs with methylation-sensitive SELEX (systematic evolution of ligands by exponential enrichment), we found that there are also many TFs that prefer CpG-methylated sequences"
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Many TFs prefer CpG-methylated sequences, most in extended homeodomain family
"Most of these are in the extended homeodomain family"
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Homeodomain specificity for methylcytosine depends on direct hydrophobic interactions
"Structural analysis showed that homeodomain specificity for methylcytosine depends on direct hydrophobic interactions with the methylcytosine 5-methyl group"
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Many developmentally important TFs from several families prefer to bind mCpG
"This study provides a systematic examination of the effect of an epigenetic DNA modification on human TF binding specificity and reveals that many developmentally important proteins display preference for mCpG-containing sequences"
Deep research report on DLX1