EMRE (CG17680) review notes

UniProt Q7JX57 (Essential MCU regulator, mitochondrial); PANTHER PTHR33904.

Literature journal

• EMRE null mutants lack fast uptake PMID:31042479.
• Fly MCU requires EMRE PMID:27099988.
• MCU:EMRE overexpression toxicity suppressed by MICU1 PMID:31042479
• Innate immunity rows come from a genome-wide RNAi survival screen (PMID:19520911); CG17680 is not named in the cached text.

Curation decisions

• contributes_to calcium channel activity ACCEPTED as core (non-pore essential subunit).
• Uniporter module conventions as in MCU-notes.md.
• Positive regulation of innate immune response marked over-annotated; defense response to Gram-negative bacterium kept as non-core.

Deep research

EMRE-deep-research-falcon.md (falcon) arrived after the review was first committed. It agrees with the review: EMRE is an essential non-pore accessory subunit of the uniporter, required for fast MCU-dependent calcium uptake (EMRE knockdown in larval muscle is not bypassed by raising MCU; three CRISPR alleles lack fast uptake). It does not discuss the innate-immunity screen rows. No annotation decision changed.