Gene Ontology annotation through association of InterPro records with GO terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping
Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins in living cells
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen.
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POLDIP2 (PDIP38) was identified as a binding partner of the p50 subunit of DNA polymerase delta
"Two novel protein partners, named PDIP38 and PDIP46, were identified from the p50 screen"
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Also interacts with PCNA
"It was found that PDIP38 also interacts with proliferating cell nuclear antigen (PCNA)"
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Contains ApaG-like C-terminal domain
"PDIP38 encodes a protein of 368 amino acids whose C terminus is conserved with the bacterial APAG protein"
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Functions as a protein-macromolecule adaptor bridging Pol delta and PCNA
"The ability of PDIP38 to interact with both the p50 subunit of pol delta and with PCNA was confirmed by pull-down assays"
PDIP38 associates with proteins constituting the mitochondrial DNA nucleoid.
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PDIP38 localizes predominantly to mitochondrial matrix
"PDIP38 is almost exclusively recovered from the mitochondrial fraction of human HeLa cells"
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Associates with mitochondrial nucleoid proteins TFAM and mtSSB (SSBP1)
"TFAM and mitochondrial single-stranded DNA binding protein (mtSSB) are co-immunoprecipitated with PDIP38 by anti-PDIP38 antibodies"
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Crosslinks to mtSSB with formaldehyde treatment
"only the latter is crosslinked to PDIP38 when mitochondria are treated with a crosslinker, formaldehyde"
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May be involved in mitochondrial DNA metabolism
"PDIP38 associates with the nucleoid components and could be involved in the metabolism of mitochondrial DNA"
The layered structure of human mitochondrial DNA nucleoids.
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Core nucleoid proteins identified by cross-linking proteomics
"A set of core nucleoid proteins is found in both native and cross-linked nucleoids, including 13 proteins with known roles in mtDNA transactions"
Crosstalk between replicative and translesional DNA polymerases: PDIP38 interacts directly with Poleta.
DNA polymerase δ-interacting protein 2 is a processivity factor for DNA polymerase λ during 8-oxo-7,8-dihydroguanine bypass.
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POLDIP2 is a processivity factor for Pol lambda during 8-oxoG bypass
"This interaction increases both the processivity and catalytic efficiency of the error-free bypass of a 8-oxo-G lesion by both Pols eta and lambda"
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Enhances both processivity and catalytic efficiency of Pol eta and Pol lambda
"This interaction increases both the processivity and catalytic efficiency of the error-free bypass of a 8-oxo-G lesion by both Pols eta and lambda, but not by Pols beta or iota"
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Facilitates switch from Pol delta to Pol lambda during TLS
"we provide evidence that PolDIP2 stimulates Pol delta without affecting its fidelity, facilitating the switch from Pol delta to Pol lambda during 8-oxo-G TLS"
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POLDIP2 silencing increases cell sensitivity to oxidative stress
"PolDIP2 silencing increases cell sensitivity to oxidative stress and its effect is further potentiated in a Pol lambda deficient background"
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Important mediator of translesion synthesis
"suggesting that PolDIP2 is an important mediator for TLS"
PolDIP2 interacts with human PrimPol and enhances its DNA polymerase activities.
Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.
Deep research report on POLDIP2
Cyberian deep research on POLDIP2 function