Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Molecular cloning of cDNAs encoding the human bombesin-like peptide neuromedin B. Chromosomal localization and comparison to cDNAs encoding its amphibian homolog ranatensin.
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Reports the molecular cloning of human prepro-neuromedin B cDNA, demonstrating that the amidated decapeptide NMB is the mammalian homolog of amphibian ranatensin.
"The amidated decapeptide neuromedin B (NMB) is the mammalian homolog of the amphibian bombesin-like peptide ranatensin."
A proteome-scale map of the human interactome network.
Role of neuromedin B and its receptor in the innate immune responses against influenza A virus infection in vitro and in vivo.
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Demonstrates that exogenous NMB signaling through NMBR enhances IFN-alpha expression and inhibits IL-6 expression during influenza A virus infection.
"The peptide neuromedin B (NMB) and its receptor (NMBR) represent a system (NMB/NMBR) of neuromodulation."
Bombesin-like receptors bind bombesin homologues
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Curates the binding of mammalian bombesin-like peptide homologs GRP and NMB to the Gq/11 coupled receptors GRPR and NMBR.
"There are two homologues of bombesin-like peptides; Gastrin-releasing peptide (GRP) (Sausville EA et al, 1986) and Neuromedin-B (NMB) (Krane IM et al, 1988)."
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq
The Ligand:GPCR:Gq complex dissociates