Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
An Upstream Open Reading Frame in Phosphatase and Tensin Homolog Encodes a Circuit Breaker of Lactate Metabolism.
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MP31 is encoded by a PTEN 5' UTR uORF and limits mitochondrial lactate-pyruvate conversion by competing with mitochondrial LDH for NAD+.
"MP31, a micropeptide encoded by the upstream open reading frame (uORF) of phosphatase and tensin homolog (PTEN) acting as a "circuit breaker" that limits lactate-pyruvate conversion in mitochondria"
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Conditional knockout of the mouse homolog in astrocytes initiates gliomagenesis.
"Conditional knockout (cKO) of MP31 homolog in mouse astrocytes initiated gliomagenesis"
Upstream open reading frame-encoded MP31 disrupts the mitochondrial quality control process and inhibits tumorigenesis in glioblastoma.
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MP31 competes with V-ATPase A1 for LDHB binding, causing lysosomal alkalinization and blocking mitophagosome-lysosome fusion in GBM cells.
"MP31 inhibited lysosome function and blocked lysosome fusion with mitophagosomes by competing with V-ATPase A1 for lactate dehydrogenase B (LDHB) binding to induce lysosomal alkalinization"
Novel Insights Into Small Open Reading Frame-Encoded Micropeptides in Glioblastoma.