Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

RGD ISO annotations to rat from other mammalian species

A complex of mammalian ufd1 and npl4 links the AAA-ATPase, p97, to ubiquitin and nuclear transport pathways.

Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains.

Involvement of the p97-Ufd1-Npl4 complex in the regulated endoplasmic reticulum-associated degradation of inositol 1,4,5-trisphosphate receptors.

Conformational changes in the AAA ATPase p97-p47 adaptor complex.

Analysis of nucleotide binding to P97 reveals the properties of a tandem AAA hexameric ATPase.

Isolation of a point-mutated p47 lacking binding affinity to p97ATPase.

Valosin-containing protein and neurofibromin interact to regulate dendritic spine density.

Distinct conformations of the protein complex p97-Ufd1-Npl4 revealed by electron cryomicroscopy.

SDF2L1 interacts with the ER-associated degradation machinery and retards the degradation of mutant proinsulin in pancreatic β-cells.

Isolation and characterization of the principal ATPase associated with transitional endoplasmic reticulum of rat liver.

p47 is a cofactor for p97-mediated membrane fusion.

Identification of the cell cycle regulator VCP (p97/CDC48) as a substrate of the band 4.1-related protein-tyrosine phosphatase PTPH1.

Valosin-containing protein is a multi-ubiquitin chain-targeting factor required in ubiquitin-proteasome degradation.

The AAA ATPase Cdc48/p97 and its partners transport proteins from the ER into the cytosol.

A membrane protein complex mediates retro-translocation from the ER lumen into the cytosol.

A novel UBA and UBX domain protein that binds polyubiquitin and VCP and is a substrate for SAPKs.

Recruitment of the p97 ATPase and ubiquitin ligases to the site of retrotranslocation at the endoplasmic reticulum membrane.

UBXD7 binds multiple ubiquitin ligases and implicates p97 in HIF1alpha turnover.

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD.

A ubiquitin ligase-associated chaperone holdase maintains polypeptides in soluble states for proteasome degradation.

Endolysosomal sorting of ubiquitylated caveolin-1 is regulated by VCP and UBXD1 and impaired by VCP disease mutations.

The AAA-ATPase VCP/p97 promotes 53BP1 recruitment by removing L3MBTL1 from DNA double-strand breaks.

Valosin-containing protein (VCP/p97) is required for poliovirus replication and is involved in cellular protein secretion pathway in poliovirus infection.

Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3.

Spatial regulation of UBXD8 and p97/VCP controls ATGL-mediated lipid droplet turnover.

Pathogenic VCP mutations induce mitochondrial uncoupling and reduced ATP levels.

Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation.

Caveolin-1 interacts with Derlin-1 and promotes ubiquitination and degradation of cyclooxygenase-2 via collaboration with p97 complex.

Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP.

Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5.

ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules.

UBXD1 is a mitochondrial recruitment factor for p97/VCP and promotes mitophagy.

The p97-UBXN1 complex regulates aggresome formation.

The ubiquitin-dependent ATPase p97 removes cytotoxic trapped PARP1 from chromatin.

TRIM55 promotes noncanonical NF-κB signaling and B cell-mediated immune responses by coordinating p100 ubiquitination and processing.

The AAA-ATPase Ter94 regulates wing size in Drosophila by suppressing the Hippo pathway.

Involvement of valosin-containing protein, an ATPase Co-purified with IkappaBalpha and 26 S proteasome, in ubiquitin-proteasome-mediated degradation of IkappaBalpha.

UniProt flat file for rat Vcp (P46462, TERA_RAT)