Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Structural basis for the heterodimeric interaction between the acute leukaemia-associated transcription factors AML1 and CBFbeta.
The RUNX1 Runt domain at 1.25A resolution: a structural switch and specifically bound chloride ions modulate DNA binding.
Cdk6 blocks myeloid differentiation by interfering with Runx1 DNA binding and Runx1-C/EBPalpha interaction.
Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development.
Defining the membrane proteome of NK cells.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
Runx1 binds as a dimeric complex to overlapping Runx1 sites within a palindromic element in the human GM-CSF enhancer.
The Runx transcriptional co-activator, CBFbeta, is essential for invasion of breast cancer cells.
Global landscape of HIV-human protein complexes.
T-cell differentiation factor CBF-β regulates HIV-1 Vif-mediated evasion of host restriction.
Structural basis for hijacking CBF-β and CUL5 E3 ligase complex by HIV-1 Vif.
Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.
Structure of the complex of adenylate kinase from Escherichia coli with the inhibitor P1,P5-di(adenosine-5'-)pentaphosphate.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
Chr21 protein-protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer's disease.
CBFβ Regulates RUNX3 ADP-Ribosylation to Mediate Homologous Recombination Repair.
Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia.
RUNX1:CBFB binds FOXP3 gene
RUNX1 and NFATC2 bind the IL2 gene promoter
RUNX1, FOXP3 and NFATC2 bind the IL2 gene promoter
RUNX1 binds the IFNG promoter
RUNX1 and FOXP3 bind the IFNG gene
RUNX1 binds intron 1 of IL2RA (CD25) gene
FOXP3 in complex with RUNX1 binds intron 1 of the IL2RA (CD25) gene
RUNX1 binds the promoter of the CTLA4 gene
FOXP3 in complex with RUNX1 binds the CTLA4 gene promoter
RUNX1 binds to TNFRSF18 (GITR) gene promoter and intron 1
FOXP3 in complex with RUNX1 binds to the TNFRSF18 (GITR) gene intron 1
RUNX1 and FOXP3 bind the RSPO3 gene promoter
RUNX2 binds SMAD1 in the nucleus
RUNX2 and SMAD1 complex binds the SMAD6 gene promoter
HIPK2 phosphorylates RUNX1 and EP300
HIPK2 phosphorylates RUNX1
RUNX1 and ESR1 bind the GPAM gene enhancer
RUNX1 and ESR1 bind the KCTD6 gene enhancer
RUNX1 and ESR1 bind the AXIN1 gene
RUNX1:CBFB binds the LIFR gene promoter
PRMT1 arginine-methylates RUNX1
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the ITGA2B promoter
RUNX1 binds SIN3A,(SIN3B) co-repressor
RUNX1 and GATA1 bind the promoter of the ITGA2B gene
RUNX1 binds the TJP1 (ZO-1) gene promoter
RUNX1 binds the OCLN gene promoter
RUNX1 binds the CLDN5 (Claudin-5) gene promoter
Core MLL complex methylates H3K4Me2-Nucleosome at the ITGA2B gene promoter
PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the GP1BA promoter
PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter
RUNX1 and GATA1 bind the promoter of the GP1BA gene
Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter
RUNX1 and GATA1 bind the promoter of the THBS1 gene
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the THBS1 gene promoter
Core MLL complex methylates H3K4Me2-Nucleosome at the THBS1 gene promoter
PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter
RUNX1 and GATA1 bind the promoter of the MIR27A gene
Core MLL complex methylates H3K4Me2-Nucleosome at the MIR27A gene promoter
PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter
RUNX1:CBFB, SIN3A(SIN3B), PRMT6 and HDAC1 bind the MIR27A gene promoter
RUNX1 binds PRC1 complexes
RUNX1:CBFB binds the NR4A3 gene promoter
RUNX1:CBFB binds the SERPINB13 gene promoter
RUNX1:CBFB binds the PRKCQ gene promoter
RUNX1:CBFB binds the PF4 gene promoter
RUNX1:CBFB binds the MYL9 gene promoter
RUNX1 binds the SWI/SNF complex
RUNX1:CBFB:CREBBP binds the CSF2 (GM-CSF) gene promoter
RUNX1:CBFB binds the NFE2 gene promoter
RUNX2:CBFB binds the LGALS3 gene promoter
RUNX1:CBFB binds the LGALS3 gene promoter
RUNX1 and ELF1 bind the IL3 gene promoter
RUNX1 and ELF1, ELF2 or PAX5 bind the BLK gene promoter
RUNX1 binds the PRKCB gene promoter
RUNX1 binds the CR1 gene promoter
RUNX2:CBFB binds the ITGA5 gene promoter
RUNX2:CBFB binds the ITGBL1 gene promoter
RUNX2:CBFB binds the MMP13 gene promoter
RUNX3:CBFB binds the ITGAL gene,(ITGA4 gene) promoter
RUNX3 binds the RUNX1 promoter
Acetylated RUNX3 binds to BRD2
CCND1 binds RUNX3 and displaces EP300
CCND1 recruits HDAC4 to RUNX3
RUNX proteins bind the p14-ARF promoter at the CDKN2A locus
RUNX1 binds the core TAL1 complex
RUNX1-containing TAL1 complex binds the MYB gene enhancer
The complex of RUNX1 and YAP1 binds the ITCH gene promoter
CDK4 phosphorylates RUNX2
PPM1D dephosphorylates RUNX2
RUNX2 binds BAX gene promoter
RUNX2:CBFB binds BGLAP gene promoter
CDK1 phosphorylates RUNX2
Activated AKT1 phosphorylates Runx2
Heterozygous pathogenic variants involving CBFB cause a new skeletal disorder resembling cleidocranial dysplasia.
A Cryptic CBFB Deletion-Inversion Expands the Mutational Spectrum of Variants Associated With Cleidocranial Dysplasia.