Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
UniProtKB entry P0DKX4 (SIM18_HUMAN), Small integral membrane protein 18
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Single predicted helical transmembrane segment; membrane location by sequence analysis only.
"FT TRANSMEM 35..55"
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Encoded within an intron of GTF2E2, on the opposite strand.
"CC -!- CAUTION: Encoded in intron of the gene GTF2E2 (opposite strand)."
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Member of the SMIM5/18/22 family that includes SMIM22 (CASIMO1).
"DR InterPro; IPR031671; SMIM5/18/22."
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RNA expression is enriched in brain, pituitary gland and retina.
"DR HPA; ENSG00000253457; Group enriched (brain, pituitary gland, retina)."
Discovery of 342 putative new genes from the analysis of 5'-end-sequenced full-length-enriched cDNA human transcripts.
The cancer-associated microprotein CASIMO1 controls cell proliferation and interacts with squalene epoxidase modulating lipid droplet formation.