Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Cadherin and catenin expression in normal human bronchial epithelium and non-small cell lung cancer.
Suppression of breast cancer invasion and migration by indole-3-carbinol: associated with up-regulation of BRCA1 and E-cadherin/catenin complexes.
The LIM protein Ajuba is recruited to cadherin-dependent cell junctions through an association with alpha-catenin.
Comprehensive proteomic analysis of breast cancer cell membranes reveals unique proteins with potential roles in clinical cancer.
Characterization of cadherin-24, a novel alternatively spliced type II cadherin.
ARHGAP10 is necessary for alpha-catenin recruitment at adherens junctions and for Listeria invasion.
Biosensor-based micro-affinity purification for the proteomic analysis of protein complexes.
Crystal structure of a beta-catenin/BCL9/Tcf4 complex.
A distinct PAR complex associates physically with VE-cadherin in vertebrate endothelial cells.
Pleiotrophin disrupts calcium-dependent homophilic cell-cell adhesion and initiates an epithelial-mesenchymal transition.
EPLIN mediates linkage of the cadherin catenin complex to F-actin and stabilizes the circumferential actin belt.
Molecular basis of actin reorganization promoted by binding of enterohaemorrhagic Escherichia coli EspB to alpha-catenin.
A human MAP kinase interactome.
Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.
Bidirectional transcription from human LRRTM2/CTNNA1 and LRRTM1/CTNNA2 gene loci leads to expression of N-terminally truncated CTNNA1 and CTNNA2 isoforms.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
Centralspindlin and α-catenin regulate Rho signalling at the epithelial zonula adherens.
Dimer asymmetry defines α-catenin interactions.
α-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-κB signalling.
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
E-cadherin interactome complexity and robustness resolved by quantitative proteomics.
Alpha-catenin-dependent recruitment of the centrosomal protein CAP350 to adherens junctions allows epithelial cells to acquire a columnar shape.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
An organelle-specific protein landscape identifies novel diseases and molecular mechanisms.
Cadherin 26 is an alpha integrin-binding epithelial receptor regulated during allergic inflammation.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Quantitative fragmentomics allow affinity mapping of interactomes.
Mapping adipocyte interactome networks by HaloTag-enrichment-mass spectrometry.
Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin.
The APC protein and E-cadherin form similar but independent complexes with alpha-catenin, beta-catenin, and plakoglobin.
Cloning of the human alpha-catenin cDNA and its aberrant mRNA in a human cancer cell line.
alpha-Catenin-vinculin interaction functions to organize the apical junctional complex in epithelial cells.
CDO binds promyogenic cadherins
Interaction of cadherin with Beta/gamma catenin, alpha catenin and p120 catenin
Nuclear translocation of p38 MAPK
PAK1-3 phosphorylates VE-cadherin
IQGAP1 binds CDH1:CTTNB1:CTTNA1 and MEN1
CDH1 associates with CTNND1
CDH1:CTNNB1 complex binds CTNNA1
CDH1-associated CTNNA1 binds VCL
CDH1 forms homotypic trans-dimers
CDH1-associated CTNNA1 binds F-actin
CDH1 is phosphorylated on tyrosine residues
Deconstructing the cadherin-catenin-actin complex.
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Alpha-catenin does not bind F-actin and the cadherin-beta-catenin complex simultaneously in solution.
"alpha-catenin does not interact with actin filaments and the E-cadherin-beta-catenin complex simultaneously"
Alpha-catenin is a molecular switch that binds E-cadherin-beta-catenin and regulates actin-filament assembly.
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Monomer binds cadherin-beta-catenin, dimer binds actin; dimer suppresses Arp2/3 actin polymerization (mouse protein, in vitro).
"Monomeric alpha-catenin binds more strongly to E-cadherin-beta-catenin, whereas the dimer preferentially binds actin filaments."
Cell adhesion. The minimal cadherin-catenin complex binds to actin filaments under force.
A polarized epithelium organized by beta- and alpha-catenin predates cadherin and metazoan origins.
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A Dictyostelium alpha-catenin ortholog binds the beta-catenin-related Aardvark and F-actin and is required for a polarized epithelium, in an organism without cadherins.
"we identify an α-catenin ortholog that binds a β-catenin-related protein"
α-catenin and IQGAP regulate myosin localization to control epithelial tube morphogenesis in Dictyostelium.
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Dictyostelium alpha-catenin and Aardvark co-localize basolaterally and organize the tip epithelium.
"The polarity and morphology of the tip epithelium require an α-catenin ortholog and the β-catenin-related protein Aardvark that co-localize to the basolateral plasma membrane"
Analysis of a vinculin homolog in a sponge (phylum Porifera) reveals that vertebrate-like cell adhesions emerged early in animal evolution.
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VIN-family proteins occur in animals and their close unicellular outgroups, including Dictyostelium.
"VIN proteins link actin filaments to membrane proteins at the plasma membrane and are found in all animals and their close outgroups (choanoflagellates, chytridomycetes, apusozoa, amoebozoa)"
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The sponge Oscarella pearsei has a separate alpha-catenin that groups with animal alpha-catenins.
"Op α-catenin grouped with other animal α-catenin sequences"
PANTHER node placement of alpha-catenin IBAs
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CTNNA1 IBAs are placed at the eumetazoan root of PTHR18914; Dictyostelium ctnnA is in the vinculin family PTHR46180.
"PTHR18914 (ALPHA CATENIN) root is PTN001052343, taxon range Eumetazoa, 85 leaves."
UniProt entry P35221 (CTNNA1_HUMAN)
Flotillin microdomains stabilize cadherins at cell-cell junctions.
The Crumbs complex couples cell density sensing to Hippo-dependent control of the TGF-β-SMAD pathway.
[Effect of intra-testicular testosterone withdrawal on the expression of alpha-catenin in the adult rat testis].
Cadherin-catenin complexes during zebrafish oogenesis: heterotypic junctions between oocytes and follicle cells.
The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.
Expression and cell membrane localization of catenins during mouse preimplantation development.
CTNNA1 source evidence and assay limits
The cadherin-catenin complex is expressed alternately with the adenomatous polyposis coli protein during rat incisor amelogenesis.
E-cadherin-catenin complex in the rat ovary: cell-specific expression during folliculogenesis and luteal formation.
Differentiation of the epithelial apical junctional complex during mouse preimplantation development: a role for rab13 in the early maturation of the tight junction.
Differential regulation of cadherins and catenins during axonal reorganization in the adult rat CNS.
Role of catenins in the development of gap junctions in rat cardiomyocytes.
Catenins in the rat epididymis: their expression and regulation in adulthood and during postnatal development.
Lamellipodium extension and cadherin adhesion: two cell responses to cadherin activation relying on distinct signalling pathways.
A unique and specific interaction between alphaT-catenin and plakophilin-2 in the area composita, the mixed-type junctional structure of cardiac intercalated discs.
Cadherins and cadherin-associated molecules in the developing and maturing rat testis.
N-cadherin in adult rat cardiomyocytes in culture. II. Spatio-temporal appearance of proteins involved in cell-cell contact and communication. Formation of two distinct N-cadherin/catenin complexes.