Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniPathway vocabulary mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Structure of the VHL-ElonginC-ElonginB complex: implications for VHL tumor suppressor function.
Tracheal development and the von Hippel-Lindau tumor suppressor homolog in Drosophila.
Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling.
Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL.
Mammalian mediator subunit mMED8 is an Elongin BC-interacting protein that can assemble with Cul2 and Rbx1 to reconstitute a ubiquitin ligase.
Suppressors of cytokine signaling 4 and 5 regulate epidermal growth factor receptor signaling.
VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases.
Towards a proteome-scale map of the human protein-protein interaction network.
The E3 ubiquitin ligase HOIL-1 induces the polyubiquitination and degradation of SOCS6 associated proteins.
COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase.
Array MAPPIT: high-throughput interactome analysis in mammalian cells.
Termination of NF-kappaB activity through a gammaherpesvirus protein that assembles an EC5S ubiquitin-ligase.
Requirement for microtubule integrity in the SOCS1-mediated intracellular dynamics of HIV-1 Gag.
An atlas of combinatorial transcriptional regulation in mouse and man.
Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes.
Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics.
Regulation of inducible nitric-oxide synthase by the SPRY domain- and SOCS box-containing proteins.
Next-generation sequencing to generate interactome datasets.
The tumour antigen PRAME is a subunit of a Cul2 ubiquitin ligase and associates with active NFY promoters.
The SOCS2 ubiquitin ligase complex regulates growth hormone receptor levels.
Toward an understanding of the protein interaction network of the human liver.
Global landscape of HIV-human protein complexes.
Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation.
The Role of Elongin BC-Containing Ubiquitin Ligases.
PRAME is a golgi-targeted protein that associates with the Elongin BC complex and is upregulated by interferon-gamma and bacterial PAMPs.
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.
Multimeric complexes among ankyrin-repeat and SOCS-box protein 9 (ASB9), ElonginBC, and Cullin 5: insights into the structure and assembly of ECS-type Cullin-RING E3 ubiquitin ligases.
A proteome-scale map of the human interactome network.
Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2).
Architecture of the human interactome defines protein communities and disease networks.
Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex.
The Eukaryotic Proteome Is Shaped by E3 Ubiquitin Ligases Targeting C-Terminal Degrons.
CRL4(AMBRA1) targets Elongin C for ubiquitination and degradation to modulate CRL5 signaling.
A glycine-specific N-degron pathway mediates the quality control of protein N-myristoylation.
BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).
A reference map of the human binary protein interactome.
A SARS-CoV-2 protein interaction map reveals targets for drug repurposing.
Structure and dynamics of the ASB9 CUL-RING E3 Ligase.
Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms.
The ZSWIM8 ubiquitin ligase mediates target-directed microRNA degradation.
The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
Molecular basis for arginine C-terminal degron recognition by Cul2(FEM1) E3 ligase.
ORF10-Cullin-2-ZYG11B complex is not required for SARS-CoV-2 infection.
Convergence of mammalian RQC and C-end rule proteolytic pathways via alanine tailing.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14(ARF) degradation.
Discovery of an exosite on the SOCS2-SH2 domain that enhances SH2 binding to phosphorylated ligands.
Rab40c regulates focal adhesions and PP6 activity by controlling ANKRD28 ubiquitylation.
A comprehensive SARS-CoV-2-human protein-protein interactome reveals COVID-19 pathobiology and potential host therapeutic targets.
Structure-based design of a phosphotyrosine-masked covalent ligand targeting the E3 ligase SOCS2.
Molecular basis for C-degron recognition by CRL2(APPBP2) ubiquitin ligase.
The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.
Molecular insights into degron recognition by CRL5(ASB7) ubiquitin ligase.
Multimodal cell maps as a foundation for structural and functional genomics.
ASB7 is a negative regulator of H3K9me3 homeostasis.
Covariation MS uncovers a protein that controls cysteine catabolism.
Inhibition of transcription elongation by the VHL tumor suppressor protein.
Elongin (SIII): a multisubunit regulator of elongation by RNA polymerase II.
Recruitment of elongation factors to form elongation complex
Addition of nucleotides leads to transcript elongation
Resumption of elongation after recovery from pausing
Abortive termination of elongation after arrest
Separation of elongating transcript from template
Formation of Elongin BC complex
Formation of Elongin complex
2-4 nt.backtracking of Pol II complex on the template leading to elongation pausing
Pol II elongation complex moves on the template as transcript elongates
TFIIS-mediated recovery of elongation from arrest
7-14 nt. Backtracking of Pol II complex on the template leading to elongation arrest
Elongating transcript encounters a lesion in the template
Proteasome proteolyzes ub-HIF-alpha
Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha
Nuclear VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
Nuclear VBC complex ubiquitinylates HIF-alpha
Cytosolic PHD2,3 hydroxylates proline residues on HIF3A
ub-hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1 translocates from the nucleus to the cytosol
Cytosolic PHD2,3 hydroxylates proline residues on HIF1A
Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
Multi-ubiquitination of APOBEC3G
Association of APOBEC3G:Vif with the Cul5-SCF complex
Proteosome-mediated degradation of APOBEC3G
CDK12 phosphorylates RNA Pol II CTD at DNA repair genes
CCNK:CDK12 binds RNA Pol II at DNA repair genes
NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex
AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex
NEDD8:AcM-UBE2M binds CRL2 E3 ubiquitin ligase complex
AcM-UBE2M transfers NEDD8 to CRL2 E3 ubiquitin ligase complex
CAND1 binds cytosolic CRL E3 ubiquitin ligases
COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes
COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds UBXN7
VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha
VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha
SOCS1,3 ubiquitinates CSF3R in SOCS1,3:p-4Y-CSF3R:CSF3 dimer:LYN:p-Y-JAK1:p-JAK2:p-SYK:p-HCK:p-TYK2:CUL5:ELOB:ELOC:RNF7
26S proteasome degrades HIFalpha
Association of NS1 (1C) with Cul5 and SCF
NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 K48 polyubiquitinates alanine-tailed nascent peptide
NEDD8-K699-CUL2:ELOB:ELOC:RBX1:KLHDC10 binds alanine-tailed nascent peptide
Falcon deep research report for human ELOC