Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain.
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin.
PEN-2 and APH-1 coordinately regulate proteolytic processing of presenilin 1.
Membrane topology of gamma-secretase component PEN-2.
The role of presenilin cofactors in the gamma-secretase complex.
APH1, PEN2, and Nicastrin increase Abeta levels and gamma-secretase activity.
Purification and characterization of the human gamma-secretase complex.
Both the sequence and length of the C terminus of PEN-2 are critical for intermolecular interactions and function of presenilin complexes.
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Cellular localization of Nicastrin affects amyloid beta species production.
Ferritin light chain interacts with PEN-2 and affects γ-secretase activity.
Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis.
Three-dimensional structure of human γ-secretase.
An atomic structure of human γ-secretase.
Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Cleavage of ERBB4m80 by gamma-scretase complex
gamma-secretase cleaves the p75NTR transmembrane domain
gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6
NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants
gamma-secretase cleaves EPHB2
Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)
NEXT3 is cleaved to produce NICD3
Gamma-secretase cleaves YBX1:NOTCH3
TGFBR3(784-851) degradation
Gamma-secretase complex cleaves mNEXT2
Gamma-secretase cleaves Notch4