GO_REF:0000024

Manual transfer of experimentally-verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10339406

Genetic and structural characterization of the human mitochondrial inner membrane translocase.

Characterized the human TIM23/TIM17/TIM44 inner-membrane translocase that drives presequence import in cooperation with mtHSP70.

PMID:12592411

Characterization of the human heart mitochondrial proteome.

Detected DNAJC19/TIM14 in the human heart mitochondrial proteome by mass spectrometry.

PMID:16055927

Mutation of DNAJC19, a human homologue of yeast inner mitochondrial membrane co-chaperones, causes DCMA syndrome, a novel autosomal recessive Barth syndrome-like condition.

Biallelic DNAJC19 variants cause dilated cardiomyopathy with ataxia (DCMA) / 3-methylglutaconic aciduria type 5, identifying DNAJC19 as a human inner-membrane import co-chaperone.

PMID:19564938

The mitochondrial protein translocation motor: structural conservation between the human and yeast Tim14/Pam18-Tim16/Pam16 co-chaperones.

J-domain proteins such as Tim14/Pam18 enhance the ATPase activity of Hsp70 chaperones to promote tight substrate binding during import; human Tim14/Pam18 and Tim16/Pam16 form heterodimeric complexes that interact with mtHSP70.

PMID:20053669

Role of Magmas in protein transport and human mitochondria biogenesis.

Human DNAJC19 stimulates Mortalin (mtHSP70) ATPase activity, which is inhibited by the Magmas:DnaJC19 complex; DNAJC19 co-precipitates with the human TIM23 translocon (hTim44, hTim23, Magmas).

PMID:34800366

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

file:human/DNAJC19/DNAJC19-uniprot.txt

UniProt entry Q96DA6 (TIM14_HUMAN), Mitochondrial import inner membrane translocase subunit TIM14

Mitochondrial co-chaperone of the PAM complex; single-pass inner-membrane protein with matrix-side J-domain; stimulates ATP-dependent import; interacts with PHB2 (prohibitin complex) and TIMM16/PAM16; cause of DCMA syndrome.