Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

UniProtKB entry O75845 (SC5D_HUMAN), Lathosterol oxidase

cDNA cloning of the mammalian sterol C5-desaturase and the expression in yeast mutant.

Lathosterolosis, a novel multiple-malformation/mental retardation syndrome due to deficiency of 3beta-hydroxysteroid-delta5-desaturase.

Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency.

7-Dehydrocholesterol is an endogenous suppressor of ferroptosis.

7-Dehydrocholesterol dictates ferroptosis sensitivity.

Expression of Lathosterol Oxidase (SC5D, SC5DL)

Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol

Cholesterol biosynthesis via desmosterol (Bloch pathway)

SC5D desaturates LTHSOL to 7-dehydroCHOL

Cholesterol biosynthesis from zymosterol (modified Kandutsch-Russell pathway)