GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

GO_REF:0000033

Annotation inferences using phylogenetic trees

PMID:18715871

PP4R4/KIAA1622 forms a novel stable cytosolic complex with phosphoprotein phosphatase 4.

Human PP4R4 binds PP4c specifically (not PP2Ac or PP6c) in a stable cytosolic complex that is independent of the PP4R1, PP4R2-PP4R3 and alpha4 complexes.

"Our data demonstrate that PP4R4 forms a novel cytosolic complex with PP4c, independent from the complexes containing PP4R1, PP4R2.PP4R3, and alpha4"

PMID:34845248

Regulation of PP2A, PP4, and PP6 holoenzyme assembly by carboxyl-terminal methylation.

PP4R4 association with PP4c is largely insensitive to loss of PP4c C-terminal methylation, unlike PP4R1.

"PP4R2, PP4R3α, and PP4R4 were mostly unaffected by the reduction in methylation"

PMID:37605615

Protein phosphatase 4 dephosphorylates phosphofructokinase-1 to regulate its enzymatic activity.

Review text in this paper places PP4R4 (with PP4R1) in the cytoplasm and states that a cellular function of PP4R4 has not been reported.

"The function of PP4R4 in cells has not been reported"

file:HORSE/PPP4R4/PPP4R4-bioinformatics/RESULTS.md

HORSE/PPP4R4/PPP4R4-bioinformatics/RESULTS.md

file:HORSE/PPP4R4/PPP4R4-bioinformatics/RESULTS-rereview.md

PPP4R4 (horse): gene-model inventory and comparison with human PPP4R4 (re-review, 2026-10-20)