Gene Ontology annotation through association of InterPro records with GO terms

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Electronic Gene Ontology annotations created by ARBA machine learning models

C. elegans MAC-1, an essential member of the AAA family of ATPases, can bind CED-4 and prevent cell death.

Translocation of C. elegans CED-4 to nuclear membranes during programmed cell death.

The Caenorhabditis elegans sex determination protein FEM-1 is a CED-3 substrate that associates with CED-4 and mediates apoptosis in mammalian cells.

Disruption of the CED-9.CED-4 complex by EGL-1 is a critical step for programmed cell death in Caenorhabditis elegans.

Demonstration of the in vivo interaction of key cell death regulators by structure-based design of second-site suppressors.

Programmed cell death mediated by ced-3 and ced-4 protects Caenorhabditis elegans from Salmonella typhimurium-mediated killing.

Subcellular localization, oligomerization, and ATP-binding of Caenorhabditis elegans CED-4.

The Caenorhabditis elegans cell death gene ced-4 encodes a novel protein and is expressed during the period of extensive programmed cell death.

Mutational analysis of the interacting cell death regulators CED-9 and CED-4.

Structure of the CED-4-CED-9 complex provides insights into programmed cell death in Caenorhabditis elegans.

Matefin/SUN-1 is a nuclear envelope receptor for CED-4 during Caenorhabditis elegans apoptosis.

Nonapoptotic role for Apaf-1 in the DNA damage checkpoint.

ced-4 and proto-oncogene tfg-1 antagonistically regulate cell size and apoptosis in C. elegans.

Inhibition of CED-3 zymogen activation and apoptosis in Caenorhabditis elegans by caspase homolog CSP-3.

Caenorhabditis elegans caspase homolog CSP-2 inhibits CED-3 autoactivation and apoptosis in germ cells.

Crystal structure of the Caenorhabditis elegans apoptosome reveals an octameric assembly of CED-4.

Autophagy and apoptosis are redundantly required for C. elegans embryogenesis.

Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans.

Programmed elimination of cells by caspase-independent cell extrusion in C. elegans.

Related F-box proteins control cell death in Caenorhabditis elegans and human lymphoma.

Both the caspase CSP-1 and a caspase-independent pathway promote programmed cell death in parallel to the canonical pathway for apoptosis in Caenorhabditis elegans.

Mechanistic insights into CED-4-mediated activation of CED-3.

Maintenance of muscle myosin levels in adult C. elegans requires both the double bromodomain protein BET-1 and sumoylation.

CED-3 caspase acts with miRNAs to regulate non-apoptotic gene expression dynamics for robust development in C. elegans.

The Cell Death Pathway Regulates Synapse Elimination through Cleavage of Gelsolin in Caenorhabditis elegans Neurons.

Regulation of CED-3 caspase localization and activation by C. elegans nuclear-membrane protein NPP-14.

Interaction between the C. elegans cell-death regulators CED-9 and CED-4.

Interaction and regulation of subcellular localization of CED-4 by CED-9.

Direct physical interaction between the Caenorhabditis elegans 'death proteins' CED-3 and CED-4.

Interaction and regulation of the Caenorhabditis elegans death protease CED-3 by CED-4 and CED-9.

Role of CED-4 in the activation of CED-3.

The death inhibitory molecules CED-9 and CED-4L use a common mechanism to inhibit the CED-3 death protease.

E1B 19,000-molecular-weight protein interacts with and inhibits CED-4-dependent, FLICE-mediated apoptosis.

WormBase gene description for ced-4 (worm)