Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

GO_REF:0000033

Annotation inferences using phylogenetic trees

GO_REF:0000044

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

GO_REF:0000052

Gene Ontology annotation based on curation of immunofluorescence data

GO_REF:0000107

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

GO_REF:0000120

Combined Automated Annotation using Multiple IEA Methods

PMID:10454579

Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation.

ASC-1 harbors a zinc-finger transactivation domain that binds basal transcription factors (TBP, TFIIA), coactivators (SRC-1, CBP/p300) and nuclear receptors; it is nuclear but cytoplasmic under serum deprivation.

PMID:12077347

Novel transcription coactivator complex containing activating signal cointegrator 1.

ASC-1 exists as a steady-state complex (with P200/ASCC3, P100/ASCC2, P50/ASCC1) and stimulates transactivation by SRF, AP-1 and NF-kappaB and relieves nuclear-receptor transrepression.

PMID:20873783

Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome.

TRIP4 interacts with the kinase NEK6 and colocalizes with NEK6 at the centrosome.

PMID:25219498

Modification of ASC1 by UFM1 is crucial for ERα transactivation and breast cancer development.

Ufmylation of ASC1/TRIP4 (promoted when ligand-bound ERalpha displaces the protease UFSP2) is required for ERalpha transactivation and assembly of an EP300/NCOA1 coactivator complex.

PMID:26924529

Mutations in Subunits of the Activating Signal Cointegrator 1 Complex Are Associated with Prenatal Spinal Muscular Atrophy and Congenital Bone Fractures.

Biallelic TRIP4 (and ASCC1) variants in the ASC-1 complex cause prenatal spinal muscular atrophy with congenital bone fractures; TRIP4 is implicated in neuromuscular junction development.

PMID:32099016

Identification of a novel trigger complex that facilitates ribosome-associated quality control in mammalian cells.

TRIP4/ASCC2/ASCC3 form the RQC-trigger (RQT) complex that facilitates ribosome-associated quality control in mammalian cells.

PMID:32579943

The ASC-1 Complex Disassembles Collided Ribosomes.

The ASC-1 complex disassembles collided ribosomes, the key mechanistic step initiating ribosome-associated quality control.

PMID:36302773

A distinct mammalian disome collision interface harbors K63-linked polyubiquitination of uS10 to trigger hRQT-mediated subunit dissociation.

K63-linked polyubiquitination of uS10 at the disome collision interface triggers hRQT/ASC-1-mediated ribosomal subunit dissociation, initiating the RQC pathway.

Reactome:R-HSA-9948291

Reactome RQC pathway (cytosol localization of ASC-1/RQT complex)

Reactome:R-HSA-9948300

Reactome RQC pathway (cytosol localization of ASC-1/RQT complex)