Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

UniProtKB entry P10253 (LYAG_HUMAN), lysosomal alpha-glucosidase

Mutation profile of the GAA gene in 40 Italian patients with late onset glycogen storage disease type II.

Integral and associated lysosomal membrane proteins.

Molecular and functional characterization of eight novel GAA mutations in Italian infants with Pompe disease.

Human lysosomal alpha-glucosidase. Characterization of the catalytic site.

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Defining the membrane proteome of NK cells.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

The molecular heterogeneity of purified human liver lysosomal alpha-glucosidase (acid alpha-glucosidase).

Structure of human lysosomal acid α-glucosidase-a guide for the treatment of Pompe disease.

Simultaneous absence of alpha-1,4-glucosidase and alpha-1,6-glucosidase activities (pH 4) in tissues of children with type II glycogen storage disease.

Leaky splicing mutation in the acid maltase gene is associated with delayed onset of glycogenosis type II.

Recombinant human acid alpha-glucosidase corrects acid alpha-glucosidase-deficient human fibroblasts, quail fibroblasts, and quail myoblasts.

Exocytosis of azurophil granule membrane proteins

Exocytosis of tertiary granule membrane proteins

Exocytosis of ficolin-rich granule membrane proteins

Glycogen breakdown (glycogenolysis)

GAA hydrolyzes lysosomal glycogen

Defective GAA does not hydrolyze lysosomal glycogen