Gene Ontology annotation through association of InterPro records with GO terms
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
Enhanced RASGEF1A expression is involved in the growth and migration of intrahepatic cholangiocarcinoma.
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Human RASGEF1A shows in vitro exchange activity on K-, H- and N-Ras; overexpression raises Ras activity and COS7 cell motility.
"RASGEF1A protein has a guanine nucleotide exchange activity to K-RAS, H-RAS, and N-RAS proteins in vitro"
RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate Rap2-specific nucleotide exchange.
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Purified RasGEF1A is a specific exchange factor for Rap2 and does not act on Rap1 or Ras-subfamily GTPases.
"Using purified RasGEF1A and RasGEF1B proteins, as well as Ras family proteins, we established that RasGEF1A and RasGEF1B function as very specific exchange factors for Rap2"
UniProt record for donkey RASGEF1A (A0A9L0J8J4)
UniProt Swiss-Prot record for human RASGEF1A (Q8N9B8)
RASGEF1A: donkey-human sequence comparison
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Donkey and human RASGEF1A are 96% identical, with both GEF domains complete.
"The donkey sequence A0A9L0J8J4 (516 residues) aligns to human Q8N9B8 (481 residues) with 96.25% identity across 480 paired residues"