Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope.
Binding of ovarian cancer antigen CA125/MUC16 to mesothelin mediates cell adhesion.
Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense.
Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Addition of galactose to Core 6 glycoprotein
C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)
Defective GALNT12 does not transfer GalNAc to mucins
Defective GALNT3 does not transfer GalNAc to mucins
A4GNT transfers GlcNAc to core 2 mucins
Defective C1GALT1C1 does not bind C1GALT1
CHST4 transfers SO4(2-) from PAPS to Core 2 mucins
GALNTs transfer GalNAc to Mucins to form Tn antigens
Addition of GlcNAc to the Tn antigen via an alpha-1,3 linkage forms a Core 5 glycoprotein
Addition of galactose to the Tn antigen via an alpha-1,3 linkage forms a Core 8 glycoprotein
Addition of GlcNAc to the Tn antigen via a beta-1,6 linkage forms a Core 6 glycoprotein
B3GNT6 transfers GlcNAc to Tn antigen
GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins
Addition of GalNAc to the Tn antigen via an alpha-1,6 linkage forms a Core 7 glycoprotein
GCNT3 transfers GlcNAc to Core 3 mucin
ST6GAL1 transfers sialic acid to Tn antigens to form sTn antigens
ST3GAL1-4 transfers sialic acid to the T antigen at the alpha 3 position
ST6GALNAC3/4 transfers sialic acid to the sialyl T antigen to form the disialyl T antigen
ST6GALNAC2 transfers sialic acid to Core 1 mucins
Functions of MUC16 in corneal epithelial cells.
UniProt record for MUC16 (Q8WXI7)