Gene Ontology annotation through association of InterPro records with GO terms
Electronic Gene Ontology annotations created by transferring manual GO annotations between related proteins based on shared sequence features
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
FluG-dependent asexual development in Aspergillus nidulans occurs via derepression.
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sfgA was identified as a suppressor of fluG and encodes a Gal4-type Zn(II)2Cys6 binuclear cluster DNA-binding protein.
"Suppressor analyses of fluG led to the identification of the sfgA gene encoding a novel protein with the Gal4-type Zn(II) 2 Cys 6 binuclear cluster DNA-binding motif at the N terminus."
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SfgA imposes the repression of conidiation that FluG signalling removes; sfgA deletion bypasses the requirement for fluG.
"indicating that the primary role of FluG is to remove repressive effects imposed by SfgA"
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SfgA acts downstream of FluG and upstream of the FlbD/FlbC/FlbB/BrlA activators.
"Genetic analyses demonstrated that SfgA functions downstream of FluG but upstream of transcriptional activators (FlbD, FlbC, FlbB, and BrlA) necessary for normal conidiation."