The research report should be a detailed narrative explaining the function, biological processes, and localization of the gene product. Citations should be given for all claims.

You should prioritize authoritative reviews and primary scientific literature when conducting research. You can supplement
this with annotations you find in gene/protein databases, but these can be outdated or inaccurate.

We are specifically interested in the primary function of the gene - for enzymes, what reaction is catalyzed, and what is the substrate specificity? For transporters, what is the substrate? For structural proteins or adapters, what is the broader structural role? For signaling molecules, what is the role in the pathway.

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Research Report: Functional Annotation of bst1 (UniProt Q9UT41; ORF SPAC824.02) in Schizosaccharomyces pombe (strain 972)

Executive summary

bst1 (Q9UT41/SPAC824.02) in fission yeast encodes an ER/early-Golgi localized membrane hydrolase of the conserved PGAP1/BST1 family, whose established family function is GPI inositol-deacylation—hydrolytic removal of the inositol 2-O–linked acyl chain on nascent GPI anchors after GPI transfer to proteins in the ER lumen. In S. pombe, bst1 loss-of-function causes ER→Golgi trafficking defects, impaired secretion, and late cytokinesis/cell separation phenotypes consistent with altered trafficking of septum-remodeling enzymes (notably glucanases). Family-level work (especially 2024 structural biology) provides a mechanistic basis for the enzyme’s substrate selectivity and catalysis, while translational studies highlight the broader importance of the pathway as an antifungal drug target (GWT1 inhibitors such as manogepix; Phase 3) and as a cause of human/animal disease phenotypes when PGAP1 is defective. (ye2025fissionyeastgpi pages 6-7, ye2025fissionyeastgpi pages 4-6, ye2025fissionyeastgpi pages 2-4, hong2024molecularbasisof pages 1-2, dai2024structuralinsightsinto pages 1-2)

1. Target verification (mandatory identity checks)

1.1 Gene/protein identity

• The target is bst1 in Schizosaccharomyces pombe (strain 972), ORF SPAC824.02, UniProt Q9UT41, annotated as a GPI inositol-deacylase and belonging to the PGAP1/BST1 family. This identity is supported by S. pombe-specific experimental work describing Bst1 as a predicted GPI inositol deacylase with ER/early Golgi localization and secretion/cytokinesis phenotypes. (ye2025fissionyeastgpi pages 1-2, ye2025fissionyeastgpi pages 4-6)

1.2 Symbol ambiguity risk

• “BST1” is also used in other organisms (e.g., budding yeast BST1; mammalian PGAP1 as the functional ortholog). These homologs were used only to support conserved biochemical mechanism, while S. pombe conclusions are anchored to S. pombe experimental evidence. (tanaka2004inositoldeacylationof pages 7-7, fujita2006inositoldeacylationby pages 1-2, hong2024molecularbasisof pages 1-2, ye2025fissionyeastgpi pages 4-6)

2. Key concepts and definitions (current understanding)

2.1 What is a GPI anchor?

Glycosylphosphatidylinositol (GPI) is a glycolipid that covalently anchors proteins to the outer leaflet of the plasma membrane. GPIs share a conserved glycan backbone and can carry different lipid moieties (diacyl-PI, 1-alkyl-2-acyl-PI, or inositol phosphoceramide). GPI anchoring confers unique trafficking and membrane organization properties (e.g., microdomain/raft association). (kinoshita2016biosynthesisofgpianchored pages 1-3)

Quantitative context:
- >150 human proteins are GPI-anchored. (kinoshita2016biosynthesisofgpianchored pages 1-3)
- >60 GPI-anchored proteins are present in budding yeast, and GPI is essential for yeast growth. (kinoshita2016biosynthesisofgpianchored pages 1-3)

2.2 Inositol acylation vs. inositol deacylation

Inositol acylation
- Early in GPI biosynthesis, the inositol 2-position of GlcN-PI is acylated (typically by PIG-W in mammals; Gwt1p in fungi/yeast), often using palmitoyl-CoA as donor, forming GlcN-(acyl)PI. This step supports efficient downstream glycan remodeling and correct GPI maturation. (kinoshita2016biosynthesisofgpianchored pages 9-11, guo2024recentresearchprogress pages 1-4)

Inositol deacylation (Bst1/PGAP1 step)
- After GPI is transferred to proteins (post-attachment), the inositol-linked acyl chain is typically removed in the ER lumen by PGAP1 (mammals) / Bst1p (yeast), restoring the free 2-OH of inositol and enabling downstream trafficking/quality control. (tanaka2004inositoldeacylationof pages 7-7, kinoshita2016biosynthesisofgpianchored pages 58-60)

Functional consequence: ER export signal
- Deacylation is required for binding to p24-family cargo receptors and recruitment of GPI-APs into COPII vesicles, promoting efficient ER export and secretion. (hong2024molecularbasisof pages 1-2)

2.3 Enzymology (reaction and substrate specificity)

Reaction (family-established; applied to S. pombe Bst1 by orthology):
- Hydrolytic cleavage of the ester-linked acyl chain attached to the 2-hydroxyl of inositol within the GPI anchor on a newly GPI-anchored protein (GPI-AP). (tanaka2004inositoldeacylationof pages 7-7, kinoshita2016biosynthesisofgpianchored pages 58-60)

Substrate specificity
- 2024 structural/biochemical work indicates PGAP1 achieves specificity by binding the lipid and glycan features of GPI-AP substrates within a specialized cavity, helping avoid indiscriminate hydrolysis of bulk membrane lipids. (hong2024molecularbasisof pages 1-2)

3. bst1 in S. pombe: molecular function, localization, and pathway role

3.1 Subcellular localization in S. pombe

Bst1 is experimentally localized to:
- Endoplasmic reticulum (ER) (cortical and nuclear envelope-associated ER) and
- Cytoplasmic puncta associated with early/cis-Golgi/ER–Golgi interface. (ye2025fissionyeastgpi pages 4-6)

Quantitative colocalization (Bst1 puncta):
- 66% overlap with Anp1-GFP (cis-Golgi/ER–Golgi transport marker)
- 12% overlap with Sec72-GFP (trans-Golgi marker) (ye2025fissionyeastgpi pages 6-7)

These data support Bst1 acting in the early secretory pathway, consistent with its conserved ER-resident deacylase role. (hong2024molecularbasisof pages 1-2, ye2025fissionyeastgpi pages 4-6)

3.2 Role in ER→Golgi trafficking and secretion

Loss of bst1 causes several markers of perturbed ER export:
- Increased numbers of COPII subunit puncta (Sec13, Sec24) (ye2025fissionyeastgpi pages 6-7)
- Altered distribution of Anp1 (accumulation at nuclear ER), suggesting early ER transport defects (ye2025fissionyeastgpi pages 4-6)
- Increased tubular ER structures (ye2025fissionyeastgpi pages 6-7)
- Reduced secretion in an acid phosphatase secretion assay (qualitatively described as significantly decreased). (ye2025fissionyeastgpi pages 6-7)

Quantitative COPII phenotype:
- Sec13 puncta per focal plane: 2.1 ± 1.6 (WT) → 8.5 ± 4.7 (bst1 mutant) (p < 0.001)
- Sec24 puncta per focal plane: 2.8 ± 1.8 (WT) → 6.2 ± 3.6 (bst1 mutant) (p < 0.001) (ye2025fissionyeastgpi pages 6-7)

Interpretation:
- These phenotypes are consistent with the conserved model where inositol deacylation by Bst1/PGAP1 is needed for efficient COPII-dependent ER export, likely by enabling p24 recognition of remodeled GPI-APs. (hong2024molecularbasisof pages 1-2)

3.3 Cytokinesis and cell separation phenotypes

bst1 loss-of-function causes prominent late cytokinesis and cell separation defects in S. pombe:
- Increased septation and multi-septated cells (ye2025fissionyeastgpi pages 4-6)
- Slower contractile-ring constriction (ye2025fissionyeastgpi pages 4-6)
- Reduced division-site localization of secreted glucanases Eng1 and Agn1, enzymes required for septum digestion and daughter separation. (ye2025fissionyeastgpi pages 6-7)

Quantitative cytokinesis/cell separation data:
- Cells with one septum: ~23% (WT) vs ~52% (bst1-s27 or bst1Δ)
- Cells with ≥2 septa: ~30% (bst1-s27 or bst1Δ)
- Contractile-ring constriction time: 34.2 ± 3.5 min (WT) vs 78.4 ± 31.5 min (bst1Δ) (p < 0.001) (ye2025fissionyeastgpi pages 4-6)

Mechanistic interpretation:
- The working model is that bst1 affects cytokinesis indirectly through secretory trafficking, reducing delivery of glucanases to the septum and thereby delaying/altering cell separation. (ye2025fissionyeastgpi pages 6-7)

3.4 Genetic interactions

A key S. pombe genetic interaction is suppression of ync13 defects:
- bst1 loss-of-function alleles (including truncation bst1-s27 and deletion) were isolated as suppressors of ync13 mutant phenotypes. (ye2025fissionyeastgpi pages 2-4)

Quantitative suppression:
- ync13 cell lysis decreased from 77% to 15% (bst1-s27) or 9% (bst1Δ). (ye2025fissionyeastgpi pages 2-4)

This suppression is consistent with bst1-mediated reduction of glucanase secretion mitigating premature/defective septum digestion in ync13-compromised cells. (ye2025fissionyeastgpi pages 6-7, ye2025fissionyeastgpi pages 2-4)

4. Conserved mechanism of BST1/PGAP1 family enzymes (expert synthesis from authoritative sources)

4.1 Primary biochemical evidence (orthologs)

• Mammalian PGAP1 and yeast Bst1p were experimentally shown to mediate inositol deacylation of GPI-APs, and loss of PGAP1 causes delayed ER→Golgi transport/maturation of GPI-APs (e.g., DAF in CHO cells); yeast BST1 complements in PGAP1-deficient cells and bst1Δ delays Gas1p maturation. (Tanaka et al., 2004-04; https://doi.org/10.1074/jbc.M313755200) (tanaka2004inositoldeacylationof pages 7-7)
• Budding-yeast bst1 disruption also affects quality control of misfolded GPI-APs retained in the ER (Gas1*p), consistent with a role in ER quality control/ERAD for GPI-APs. (Fujita et al., 2006-02; https://doi.org/10.1091/mbc.e05-05-0443) (fujita2006inositoldeacylationby pages 1-2)

4.2 Latest mechanistic/structural advance (2024)

A major 2024 advance is high-resolution structural elucidation of PGAP1:
- Three PGAP1 structures at 2.66–2.84 Å reveal a 10-transmembrane architecture, a specialized “guitar-shaped” cavity organizing acyl chains, and serine hydrolase-type catalysis with atypical features, explaining substrate fidelity and providing a framework for how inositol deacylation couples to sorting/quality control. (Hong et al., 2024-01; Nature Communications; https://doi.org/10.1038/s41467-023-44568-2) (hong2024molecularbasisof pages 1-2)

Visual evidence from the paper (structures/architecture/cavity) is captured in the extracted figure crops. (hong2024molecularbasisof media 4f394f47, hong2024molecularbasisof media 544f2062, hong2024molecularbasisof media 3efecb2e)

5. Recent developments (2023–2024) in the broader pathway relevant to bst1 functional interpretation

5.1 Updated conceptual framing and chemical biology (2024)

A 2024 Current Opinion review summarizes recent progress in:
- GPI-AP biosynthesis and membrane interactions
- Quality control links (including ubiquitin-associated components at GPI-T)
- Chemical/chemoenzymatic synthesis and metabolic labeling tools for GPI/GPI-APs (e.g., azide-functionalized PI derivatives for incorporation into GPIs). (Guo & Kundu, 2024-02; https://doi.org/10.1016/j.cbpa.2023.102421) (guo2024recentresearchprogress pages 4-5)

Relevance to bst1:
- These developments improve experimental ability to test Bst1-mediated remodeling effects (e.g., through lipid probes or synthetic substrates) and emphasize that lipid-remodeling steps act as sorting signals in secretory trafficking—consistent with S. pombe phenotypes. (ye2025fissionyeastgpi pages 6-7, guo2024recentresearchprogress pages 4-5)

5.2 Adjacent remodeling enzymes and comparative biology (2023)

• In Trypanosoma brucei, a 2023 study identified a GPI-specific phospholipase A2 (GPI-PLA2) involved in fatty-acid remodeling, illustrating ongoing discovery of remodeling enzymes and highlighting differences in where remodeling occurs (pre- vs post-transfer) across eukaryotes. (Ji et al., 2023-08; J Biol Chem; https://doi.org/10.1016/j.jbc.2023.105016) (ji2023identificationofthe pages 1-2)

6. Current applications and real-world implementations

6.1 Antifungal drug development targeting the pathway

Although bst1 itself is not the primary clinical target, the same pathway is actively exploited therapeutically.

Manogepix targets fungal GWT1 (inositol acyltransferase), an upstream step complementary to Bst1/PGAP1 deacylation.
- Manogepix has advanced to Phase 3 and has FDA orphan drug designation. (Hong et al., 2024-01) (hong2024molecularbasisof pages 1-2)
- 2024 cryo-EM structures of yeast GWT1 bound to palmitoyl-CoA (3.3 Å) and manogepix (3.5 Å) show competitive inhibition by manogepix occupying the palmitoyl-CoA cavity and reveal a unique 13-TM architecture, enabling structure-guided antifungal optimization. (Dai et al., 2024-10; Nature Communications; https://doi.org/10.1038/s41467-024-53512-x) (dai2024structuralinsightsinto pages 1-2)

6.2 Antifungal stress physiology and combination strategies (2024)

In Candida glabrata, inhibition of GPI-anchor biosynthesis by manogepix triggers stress pathways:
- A 2024 genome-scale fitness study found 87 gene deficiencies that depend on calcineurin signaling for viability under FK506, and reported that ~80% of FK506-sensitive mutants were linked to vesicular trafficking processes; manogepix increased calcineurin signaling and calcineurin prevented cell death independent of Crz1, implying potential combination strategies to potentiate antifungal activity. (Pavesic et al., 2024-01; mSphere; https://doi.org/10.1128/msphere.00554-23) (pavesic2024calcineurindependentcontributionsto pages 1-2)

6.3 Human/animal physiology and disease relevance of PGAP1 (Bst1 ortholog)

• Review evidence indicates human individuals with PGAP1 mutations have forebrain abnormalities, and male Pgap1-knockout mice are infertile due to sperm migration/adhesion defects, linking inositol deacylation to organismal physiology. (Kinoshita & Fujita, 2016-01; https://doi.org/10.1194/jlr.R063313) (kinoshita2016biosynthesisofgpianchored pages 22-24)

These translational links support the general conclusion that the inositol deacylation step is physiologically critical, strengthening inference that S. pombe Bst1 is functionally important even if not essential for viability under all conditions. (ye2025fissionyeastgpi pages 6-7, kinoshita2016biosynthesisofgpianchored pages 22-24)

7. Statistics and data highlights (from included sources)

• S. pombe Bst1 puncta overlap with cis-Golgi marker Anp1: 66%; with trans-Golgi marker Sec72: 12% (ye2025fissionyeastgpi pages 6-7)
• COPII puncta increase in bst1 mutants: Sec13 2.1 ± 1.6 → 8.5 ± 4.7, Sec24 2.8 ± 1.8 → 6.2 ± 3.6 (p < 0.001) (ye2025fissionyeastgpi pages 6-7)
• Cytokinesis phenotype: ring constriction time 34.2 ± 3.5 min (WT) vs 78.4 ± 31.5 min (bst1Δ) (p < 0.001) (ye2025fissionyeastgpi pages 4-6)
• Septation phenotype: ~23% WT one septum vs ~52% bst1 one septum; ~30% bst1 with ≥2 septa (ye2025fissionyeastgpi pages 4-6)
• Genetic suppression: ync13 lysis 77% → 15% (bst1-s27) or 9% (bst1Δ) (ye2025fissionyeastgpi pages 2-4)
• Structural statistics (PGAP1): resolution 2.66–2.84 Å, 10 TM architecture (hong2024molecularbasisof pages 1-2)
• Structural statistics (GWT1): cryo-EM 3.3 Å (substrate) and 3.5 Å (manogepix), 13 TM fold (dai2024structuralinsightsinto pages 1-2)
• GPI-AP prevalence: >150 human GPI-APs; >60 budding yeast GPI-APs (kinoshita2016biosynthesisofgpianchored pages 1-3); ~300 predicted plant GPI-APs (~10% of secreted proteins) (bernatsilvestre2021atpgap1functionsas pages 1-2)
• Calcineurin fitness screen: 87 gene deficiencies; ~80% related to vesicular trafficking (pavesic2024calcineurindependentcontributionsto pages 1-2)

8. Consolidated functional annotation for S. pombe bst1 (Q9UT41)

8.1 Primary molecular function (most supported)

Bst1 is best annotated as a GPI inositol-deacylase (post-attachment GPI lipid remodeling enzyme) in the ER lumen, impacting ER export/secretory trafficking by enabling proper GPI-anchor remodeling and subsequent cargo-receptor/COPII-mediated transport. (tanaka2004inositoldeacylationof pages 7-7, hong2024molecularbasisof pages 1-2, ye2025fissionyeastgpi pages 6-7, ye2025fissionyeastgpi pages 4-6)

8.2 Cellular role and pathway placement

In fission yeast, the bst1 phenotype pattern supports a role in:
- Early secretory pathway organization (ER/early Golgi)
- Secretion and targeting of enzymes required for septum digestion and cell separation
- Coupling of GPI remodeling to cell-cycle–linked morphogenesis. (ye2025fissionyeastgpi pages 6-7, ye2025fissionyeastgpi pages 4-6)

Summary table

The following table consolidates the best-supported annotation elements and their evidence.

Table: This table summarizes the current functional annotation of Schizosaccharomyces pombe bst1 (SPAC824.02/Q9UT41), integrating direct fission-yeast evidence with conserved mechanistic evidence from BST1/PGAP1 family studies. It highlights the enzyme’s reaction, pathway role, localization, phenotypes, quantitative findings, and cross-species support.

Limitations of the current evidence base

• Direct biochemical demonstration of inositol deacylase activity for S. pombe Bst1 (e.g., in vitro enzymatic assay on purified protein or direct lipidomic confirmation of inositol deacylation state) was not present in the S. pombe evidence excerpts available here; the enzymatic reaction is inferred strongly from conserved family function and from the S. pombe localization/trafficking phenotypes. (ye2025fissionyeastgpi pages 4-6, tanaka2004inositoldeacylationof pages 7-7, hong2024molecularbasisof pages 1-2)

Key cited sources (URLs and publication dates)

• Ye Y. et al. “Fission yeast GPI inositol deacylase Bst1 regulates ER–Golgi transport and functions in late stages of cytokinesis.” Molecular Biology of the Cell (published 2025-03). https://doi.org/10.1091/mbc.e24-08-0375 (ye2025fissionyeastgpi pages 4-6)
• Hong J. et al. “Molecular basis of the inositol deacylase PGAP1 involved in quality control of GPI-AP biogenesis.” Nature Communications (published 2024-01). https://doi.org/10.1038/s41467-023-44568-2 (hong2024molecularbasisof pages 1-2)
• Dai X. et al. “Structural insights into the inhibition mechanism of fungal GWT1 by manogepix.” Nature Communications (published 2024-10). https://doi.org/10.1038/s41467-024-53512-x (dai2024structuralinsightsinto pages 1-2)
• Guo Z., Kundu S. “Recent research progress in GPI-anchored protein biosynthesis…” Current Opinion in Chemical Biology (published 2024-02). https://doi.org/10.1016/j.cbpa.2023.102421 (guo2024recentresearchprogress pages 4-5)
• Tanaka S. et al. “Inositol Deacylation … mediated by mammalian PGAP1 and yeast Bst1p.” J. Biol. Chem. (published 2004-04). https://doi.org/10.1074/jbc.M313755200 (tanaka2004inositoldeacylationof pages 7-7)
• Fujita M. et al. “Inositol Deacylation by Bst1p is required for the quality control of GPI-APs.” Molecular Biology of the Cell (published 2006-02). https://doi.org/10.1091/mbc.e05-05-0443 (fujita2006inositoldeacylationby pages 1-2)
• Kinoshita T., Fujita M. “Biosynthesis of GPI-anchored proteins: special emphasis on GPI lipid remodeling.” Journal of Lipid Research (published 2016-01). https://doi.org/10.1194/jlr.R063313 (kinoshita2016biosynthesisofgpianchored pages 1-3)
• Pavesic M.W. et al. “Calcineurin-dependent contributions to fitness in Candida glabrata.” mSphere (published 2024-01). https://doi.org/10.1128/msphere.00554-23 (pavesic2024calcineurindependentcontributionsto pages 1-2)

References

1. (ye2025fissionyeastgpi pages 6-7): Yanfang Ye, Aysha H. Osmani, Zhen-Ru Liu, Addie Kern, and Jian-Qiu Wu. Fission yeast gpi inositol deacylase bst1 regulates er-golgi transport and functions in late stages of cytokinesis. Mar 2025. URL: https://doi.org/10.1091/mbc.e24-08-0375, doi:10.1091/mbc.e24-08-0375. This article has 6 citations and is from a domain leading peer-reviewed journal.

2. (ye2025fissionyeastgpi pages 4-6): Yanfang Ye, Aysha H. Osmani, Zhen-Ru Liu, Addie Kern, and Jian-Qiu Wu. Fission yeast gpi inositol deacylase bst1 regulates er-golgi transport and functions in late stages of cytokinesis. Mar 2025. URL: https://doi.org/10.1091/mbc.e24-08-0375, doi:10.1091/mbc.e24-08-0375. This article has 6 citations and is from a domain leading peer-reviewed journal.

3. (ye2025fissionyeastgpi pages 2-4): Yanfang Ye, Aysha H. Osmani, Zhen-Ru Liu, Addie Kern, and Jian-Qiu Wu. Fission yeast gpi inositol deacylase bst1 regulates er-golgi transport and functions in late stages of cytokinesis. Mar 2025. URL: https://doi.org/10.1091/mbc.e24-08-0375, doi:10.1091/mbc.e24-08-0375. This article has 6 citations and is from a domain leading peer-reviewed journal.

4. (hong2024molecularbasisof pages 1-2): Jingjing Hong, Tingting Li, Yulin Chao, Yidan Xu, Zhini Zhu, Zixuan Zhou, Weijie Gu, Qianhui Qu, and Dianfan Li. Molecular basis of the inositol deacylase pgap1 involved in quality control of gpi-ap biogenesis. Nature Communications, Jan 2024. URL: https://doi.org/10.1038/s41467-023-44568-2, doi:10.1038/s41467-023-44568-2. This article has 16 citations and is from a highest quality peer-reviewed journal.

5. (dai2024structuralinsightsinto pages 1-2): Xinli Dai, Xuanzhong Liu, Jialu Li, Hui Chen, Chuangye Yan, Yaozong Li, Hanmin Liu, Dong Deng, and Xiang Wang. Structural insights into the inhibition mechanism of fungal gwt1 by manogepix. Nature Communications, Oct 2024. URL: https://doi.org/10.1038/s41467-024-53512-x, doi:10.1038/s41467-024-53512-x. This article has 21 citations and is from a highest quality peer-reviewed journal.

6. (ye2025fissionyeastgpi pages 1-2): Yanfang Ye, Aysha H. Osmani, Zhen-Ru Liu, Addie Kern, and Jian-Qiu Wu. Fission yeast gpi inositol deacylase bst1 regulates er-golgi transport and functions in late stages of cytokinesis. Mar 2025. URL: https://doi.org/10.1091/mbc.e24-08-0375, doi:10.1091/mbc.e24-08-0375. This article has 6 citations and is from a domain leading peer-reviewed journal.

7. (tanaka2004inositoldeacylationof pages 7-7): Satoshi Tanaka, Yusuke Maeda, Yuko Tashima, and Taroh Kinoshita. Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian pgap1 and yeast bst1p*. Journal of Biological Chemistry, 279:14256-14263, Apr 2004. URL: https://doi.org/10.1074/jbc.m313755200, doi:10.1074/jbc.m313755200. This article has 233 citations and is from a domain leading peer-reviewed journal.

8. (fujita2006inositoldeacylationby pages 1-2): Morihisa Fujita, Takehiko Yoko-o, and Yoshifumi Jigami. Inositol deacylation by bst1p is required for the quality control of glycosylphosphatidylinositol-anchored proteins. Feb 2006. URL: https://doi.org/10.1091/mbc.e05-05-0443, doi:10.1091/mbc.e05-05-0443. This article has 122 citations and is from a domain leading peer-reviewed journal.

9. (kinoshita2016biosynthesisofgpianchored pages 1-3): Taroh Kinoshita and Morihisa Fujita. Biosynthesis of gpi-anchored proteins: special emphasis on gpi lipid remodeling. Journal of Lipid Research, 57:24-6, Jan 2016. URL: https://doi.org/10.1194/jlr.r063313, doi:10.1194/jlr.r063313. This article has 307 citations and is from a peer-reviewed journal.

10. (kinoshita2016biosynthesisofgpianchored pages 9-11): Taroh Kinoshita and Morihisa Fujita. Biosynthesis of gpi-anchored proteins: special emphasis on gpi lipid remodeling. Journal of Lipid Research, 57:24-6, Jan 2016. URL: https://doi.org/10.1194/jlr.r063313, doi:10.1194/jlr.r063313. This article has 307 citations and is from a peer-reviewed journal.

11. (guo2024recentresearchprogress pages 1-4): Zhongwu Guo and Sayan Kundu. Recent research progress in glycosylphosphatidylinositol-anchored protein biosynthesis, chemical/chemoenzymatic synthesis, and interaction with the cell membrane. Current Opinion in Chemical Biology, 78:102421, Feb 2024. URL: https://doi.org/10.1016/j.cbpa.2023.102421, doi:10.1016/j.cbpa.2023.102421. This article has 10 citations and is from a peer-reviewed journal.

12. (kinoshita2016biosynthesisofgpianchored pages 58-60): Taroh Kinoshita and Morihisa Fujita. Biosynthesis of gpi-anchored proteins: special emphasis on gpi lipid remodeling. Journal of Lipid Research, 57:24-6, Jan 2016. URL: https://doi.org/10.1194/jlr.r063313, doi:10.1194/jlr.r063313. This article has 307 citations and is from a peer-reviewed journal.

13. (hong2024molecularbasisof media 4f394f47): Jingjing Hong, Tingting Li, Yulin Chao, Yidan Xu, Zhini Zhu, Zixuan Zhou, Weijie Gu, Qianhui Qu, and Dianfan Li. Molecular basis of the inositol deacylase pgap1 involved in quality control of gpi-ap biogenesis. Nature Communications, Jan 2024. URL: https://doi.org/10.1038/s41467-023-44568-2, doi:10.1038/s41467-023-44568-2. This article has 16 citations and is from a highest quality peer-reviewed journal.

14. (hong2024molecularbasisof media 544f2062): Jingjing Hong, Tingting Li, Yulin Chao, Yidan Xu, Zhini Zhu, Zixuan Zhou, Weijie Gu, Qianhui Qu, and Dianfan Li. Molecular basis of the inositol deacylase pgap1 involved in quality control of gpi-ap biogenesis. Nature Communications, Jan 2024. URL: https://doi.org/10.1038/s41467-023-44568-2, doi:10.1038/s41467-023-44568-2. This article has 16 citations and is from a highest quality peer-reviewed journal.

15. (hong2024molecularbasisof media 3efecb2e): Jingjing Hong, Tingting Li, Yulin Chao, Yidan Xu, Zhini Zhu, Zixuan Zhou, Weijie Gu, Qianhui Qu, and Dianfan Li. Molecular basis of the inositol deacylase pgap1 involved in quality control of gpi-ap biogenesis. Nature Communications, Jan 2024. URL: https://doi.org/10.1038/s41467-023-44568-2, doi:10.1038/s41467-023-44568-2. This article has 16 citations and is from a highest quality peer-reviewed journal.

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17. (ji2023identificationofthe pages 1-2): Zhe Ji, Rupa Nagar, Samuel M. Duncan, Maria Lucia Sampaio Guther, and Michael A.J. Ferguson. Identification of the glycosylphosphatidylinositol-specific phospholipase a2 (gpi-pla2) that mediates gpi fatty acid remodeling in trypanosoma brucei. Journal of Biological Chemistry, 299:105016, Aug 2023. URL: https://doi.org/10.1016/j.jbc.2023.105016, doi:10.1016/j.jbc.2023.105016. This article has 7 citations and is from a domain leading peer-reviewed journal.

18. (pavesic2024calcineurindependentcontributionsto pages 1-2): Matthew W. Pavesic, Andrew N. Gale, Timothy J. Nickels, Abigail A. Harrington, Maya Bussey, and Kyle W. Cunningham. Calcineurin-dependent contributions to fitness in the opportunistic pathogen candida glabrata. Jan 2024. URL: https://doi.org/10.1128/msphere.00554-23, doi:10.1128/msphere.00554-23. This article has 14 citations and is from a peer-reviewed journal.

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22. (bernatsilvestre2021functionofatpgap1ingpi pages 1-4): César Bernat-Silvestre, Judit Sanchez-Simarro, Yingxuan Ma, Kim Johnson, Fernando Aniento, and María Jesús Marcote. Function ofatpgap1in gpi anchor lipid remodeling and transport to the cell surface of gpi-anchored proteins. BioRxiv, Mar 2021. URL: https://doi.org/10.1101/2021.03.09.434604, doi:10.1101/2021.03.09.434604. This article has 0 citations.

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Citations

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