Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Combined Automated Annotation using Multiple IEA Methods

Examining thrombin hydrolysis of the factor XIII activation peptide segment leads to a proposal for explaining the cardioprotective effects observed with the factor XIII V34L mutation.

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability.

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

Coagulation Factor XIIIA Subunit Missense Mutations Affect Structure and Function at the Various Steps of Factor XIII Action.

Proteomic characterization of human multiple myeloma bone marrow extracellular matrix.

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta.

Characterization of cDNA coding for human factor XIIIa.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Human Factor XIII from plasma and platelets. Molecular weights, subunit structures, proteolytic activation, and cross-linking of fibrinogen and fibrin.

factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides

factor XIII cleaved tetramer + 2 Ca++ -> factor XIIIa + 2 factor XIII B chain

fibrin multimer -> fibrin multimer, crosslinked + NH4+

Exocytosis of platelet alpha granule contents

Expression of IL4, IL13-upregulated extracellular proteins

αIIbβ3:fibrin multimer ->αIIbβ3:fibrin multimer, crosslinked + NH4+

Functional factor XIII-A is exposed on the stimulated platelet surface.

Activated platelets retain and protect most of their factor XIII-A cargo from proteolytic activation and degradation.

Packaging zinc, fibrinogen, and factor XIII in platelet alpha-granules.

Targeted inactivation of the mouse locus encoding coagulation factor XIII-A: hemostatic abnormalities in mutant mice and characterization of the coagulation deficit.

Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice.

Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by x-ray crystallography.

UniProt P00488: human coagulation factor XIII A chain