Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

AHNAK, a protein that binds and activates phospholipase C-gamma1 in the presence of arachidonic acid.

The giant protein AHNAK is a specific target for the calcium- and zinc-binding S100B protein: potential implications for Ca2+ homeostasis regulation by S100B.

Protein kinase B phosphorylates AHNAK and regulates its subcellular localization.

The carboxyl-terminal region of ahnak provides a link between cardiac L-type Ca2+ channels and the actin-based cytoskeleton.

AHNAK interaction with the annexin 2/S100A10 complex regulates cell membrane cytoarchitecture.

The carboxyl-terminal ahnak domain induces actin bundling and stabilizes muscle contraction.

AHNAK-mediated activation of phospholipase C-gamma1 through protein kinase C.

AHNAK interacts with the DNA ligase IV-XRCC4 complex and stimulates DNA ligase IV-mediated double-stranded ligation.

Systematic identification of hepatocellular proteins interacting with NS5A of the hepatitis C virus.

A human gene (AHNAK) encoding an unusually large protein with a 1.2-microns polyionic rod structure.

Ahnak is critical for cardiac Ca(V)1.2 calcium channel function and its beta-adrenergic regulation.

Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer.

AHNAK, a novel component of the dysferlin protein complex, redistributes to the cytoplasm with dysferlin during skeletal muscle regeneration.

Integral and associated lysosomal membrane proteins.

Ahnak protein activates protein kinase C (PKC) through dissociation of the PKC-protein phosphatase 2A complex.

A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation.

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).

Dynamic interactions between L-type voltage-sensitive calcium channel Cav1.2 subunits and ahnak in osteoblastic cells.

Requirement for AHNAK1-mediated calcium signaling during T lymphocyte cytolysis.

Defining the membrane proteome of NK cells.

Regulation of epidermal growth factor receptor trafficking by lysine deacetylase HDAC6.

Ahnak1 modulates L-type Ca(2+) channel inactivation of rodent cardiomyocytes.

AHNAK1 and AHNAK2 are costameric proteins: AHNAK1 affects transverse skeletal muscle fiber stiffness.

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation.

Self-regulated alternative splicing at the AHNAK locus.

Ahnak1 abnormally localizes in muscular dystrophies and contributes to muscle vesicle release.

Ahnak1 interaction is affected by phosphorylation of Ser-296 on Cavβ₂.

Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

Structure of an asymmetric ternary protein complex provides insight for membrane interaction.

Function of Ahnak protein in aortic smooth muscle cell migration through Rac activation.

Structure of a C-terminal AHNAK peptide in a 1:2:2 complex with S100A10 and an acetylated N-terminal peptide of annexin A2.

SMARCA3, a chromatin-remodeling factor, is required for p11-dependent antidepressant action.

Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers.

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.

Giant scaffolding protein AHNAK1 interacts with β-dystroglycan and controls motility and mechanical properties of Schwann cells.

E-cadherin interactome complexity and robustness resolved by quantitative proteomics.

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

∆F508 CFTR interactome remodelling promotes rescue of cystic fibrosis.

AHNAK enables mammary carcinoma cells to produce extracellular vesicles that increase neighboring fibroblast cell motility.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei.

Ahnak scaffolds p11/Anxa2 complex and L-type voltage-gated calcium channel and modulates depressive behavior.

A protein-interaction network of interferon-stimulated genes extends the innate immune system landscape.

A pathogenic CtBP1 missense mutation causes altered cofactor binding and transcriptional activity.

The submembranous location of p11 and its interaction with the p36 substrate of pp60 src kinase in situ.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

AHNAK controls 53BP1-mediated p53 response by restraining 53BP1 oligomerization and phase separation.

Differential CFTR-Interactome Proximity Labeling Procedures Identify Enrichment in Multiple SLC Transporters.

Quantitative fragmentomics allow affinity mapping of interactomes.

Systematic identification of post-transcriptional regulatory modules.

The human gene AHNAK encodes a large phosphoprotein located primarily in the nucleus.

Affinage mechanistic annotation for AHNAK (human)

UniProt entry Q09666 (AHNK_HUMAN) as downloaded for this review