Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Human ligands of the Notch receptor.
Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors.
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Delta1, Jagged1 and Jagged2 bind directly to Notch1/Notch3 ectodomains in a calcium-dependent manner.
"All interactions between the DSL proteins and soluble Notch proteins were dependent on Ca(2+)."
Differential effects of Notch ligands Delta-1 and Jagged-1 in human lymphoid differentiation.
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DLL1 blocks B-lineage and promotes T/NK precursors from human progenitors.
"the Notch ligand Delta-1 completely inhibits the differentiation of human hematopoietic progenitors into the B cell lineage while promoting the emergence of cells with a phenotype of T cell/natural killer (NK) precursors."
Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain.
The stem cell compartment in human interfollicular epidermis.
Delta proteins and MAGI proteins: an interaction of Notch ligands with intracellular scaffolding molecules and its significance for zebrafish development.
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Delta1/Delta4 C-terminal ATEV motif binds MAGI PDZ4.
"We show that these Deltas associate with the membrane-associated scaffolding proteins MAGI1, MAGI2 and MAGI3, through a direct interaction between the C termini of the Deltas and a specific PDZ domain (PDZ4) of the MAGIs."
Notch signaling is required for maintaining stem-cell features of neuroprogenitor cells derived from human embryonic stem cells.
The CD46-Jagged1 interaction is critical for human TH1 immunity.
Intrinsic selectivity of Notch 1 for Delta-like 4 over Delta-like 1.
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MNNL-EGF3 region of DLL1 is necessary and sufficient for Notch1 activation.
"Truncation studies of the Dll1 and Dll4 ectodomains showed that the MNNL-EGF3 region was both necessary and sufficient for full activation."
Synaptojanin-2 binding protein stabilizes the Notch ligands DLL1 and DLL4 and inhibits sprouting angiogenesis.
Human-Specific NOTCH2NL Genes Expand Cortical Neurogenesis through Delta/Notch Regulation.
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NOTCH2NL activate Notch by inhibiting cis Delta/Notch interactions.
"At the molecular level, NOTCH2NL function by activating the Notch pathway through inhibition of cis Delta/Notch interactions."
Quantitative fragmentomics allow affinity mapping of interactomes.
ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants
NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding
NOTCH1 t(7;9)(NOTCH1:M1580_K2555) does not bind DLL1
NOTCH1 HD domain mutants bind DLL1
NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants
NOTCH1 PEST domain mutants bind DLL1
NOTCH1 HD+PEST domain mutants bind DLL1
Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants
NOTCH3-ligand complex is cleaved to produce NEXT3
NOTCH2NLB, (NOTCH2NLA, NOTCH2NLC) bind DLL1, (DLL4, JAG1, JAG2)
Falcon deep research report on human DLL1
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DLL1 carries a DOS motif in EGF1-2, unlike DLL4.
"Unlike the closely related ligand DLL4, DLL1 contains a DOS (Delta and OSM-11-like proteins) motif within its first two EGF repeats, which contributes to its distinctive receptor-binding mechanism"
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Ligand ubiquitination is required for force-generating endocytosis.
"This ubiquitination is essential for converting surface DLL1 into a signaling-competent ligand capable of generating the mechanical force required for Notch activation"
UniProtKB entry O00548 (DLL1_HUMAN)