Class I MHC mediated antigen processing & presentation
Small sequence variations between two mammalian paralogs of the small GTPase SAR1 underlie functional differences in coat protein complex II assembly.
The alarmone ppGpp selectively inhibits the isoform A of the human small GTPase Sar1.
Annotation inferences using phylogenetic trees
Gene Ontology annotation through association of InterPro records with GO terms
Disassembly of COPII coated vesicle
Gene Ontology annotation based on Enzyme Commission mapping
Architecture of the human interactome defines protein communities and disease networks.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
SAR1B senses leucine levels to regulate mTORC1 signalling.
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Cargo selection in endoplasmic reticulum-to-Golgi transport and relevant diseases.
Receptor-Mediated ER Export of Lipoproteins Controls Lipid Homeostasis in Mice and Humans.
SAR1 Activation And Membrane Binding
SEC31:SEC13 and v-SNARE recruitment
Formation of COPII vesicle
Fusion of COPII vesicle with Golgi complex
SEC16 complex binds SAR1B:GTP:SEC23:SEC24
Inner coat assembly and cargo binding
Budding of COPII coated vesicle
Recruitment of Sec31p:Sec13p to prebudding complex and formation of COPII vesicle
Capturing cargo and formation of prebudding complex
Silencing of mammalian Sar1 isoforms reveals COPII-independent protein sorting and transport.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Electronic Gene Ontology annotations created by ARBA machine learning models
TMEM41B acts as an ER scramblase required for lipoprotein biogenesis and lipid homeostasis.
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders.
Understanding Chylomicron Retention Disease Through Sar1b Gtpase Gene Disruption: Insight From Cell Culture.
The endoplasmic reticulum coat protein II transport machinery coordinates cellular lipid secretion and cholesterol biosynthesis.
Animal model of Sar1b deficiency presents lipid absorption deficits similar to Anderson disease.
Molecular analysis and intestinal expression of SAR1 genes and proteins in Anderson's disease (Chylomicron retention disease).
Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease.
UniProt entry Q9Y6B6 (SAR1B_HUMAN)