Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein.
EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.
Suz12 is essential for mouse development and for EZH2 histone methyltransferase activity.
The human tumor antigen PRAME is a dominant repressor of retinoic acid receptor signaling.
The Polycomb group protein EZH2 directly controls DNA methylation.
The polycomb group protein EZH2 is required for mammalian circadian clock function.
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia.
MYC stimulates EZH2 expression by repression of its negative regulator miR-26a.
Dynamic Histone H1 Isotype 4 Methylation and Demethylation by Histone Lysine Methyltransferase G9a/KMT1C and the Jumonji Domain-containing JMJD2/KDM4 Proteins.
The histone variant macroH2A is an epigenetic regulator of key developmental genes.
JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells.
An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-kappaB.
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In human prostate epithelial cells, EZH2 represses DAB2IP and promotes Ras-GTP signaling; DAB2IP reconstitution reverses these effects, distinguishing signaling activation from increased GTP hydrolysis.
Role for the MOV10 RNA helicase in polycomb-mediated repression of the INK4a tumor suppressor.
Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27.
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands.
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).
Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics.
ASXL1 mutations promote myeloid transformation through loss of PRC2-mediated gene repression.
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity.
Molecular basis for H3K36me3 recognition by the Tudor domain of PHF1.
CRL4B catalyzes H2AK119 monoubiquitination and coordinates with PRC2 to promote tumorigenesis.
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting.
A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells.
A Y2H-seq approach defines the human protein methyltransferase interactome.
Phosphorylation of EZH2 activates STAT3 signaling via STAT3 methylation and promotes tumorigenicity of glioblastoma stem-like cells.
Dnmt3L antagonizes DNA methylation at bivalent promoters and favors DNA methylation at gene bodies in ESCs.
Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas.
O-GlcNAcylation regulates EZH2 protein stability and function.
A KRAS-directed transcriptional silencing pathway that mediates the CpG island methylator phenotype.
Human-chromatin-related protein interactions identify a demethylase complex required for chromosome segregation.
A proteome-scale map of the human interactome network.
ATRX directs binding of PRC2 to Xist RNA and Polycomb targets.
Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3.
Weaver Syndrome-Associated EZH2 Protein Variants Show Impaired Histone Methyltransferase Function In Vitro.
A High-Density Map for Navigating the Human Polycomb Complexome.
N-Myc Induces an EZH2-Mediated Transcriptional Program Driving Neuroendocrine Prostate Cancer.
Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.
Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome.
Structures of human PRC2 with its cofactors AEBP2 and JARID2.
A Family of Vertebrate-Specific Polycombs Encoded by the LCOR/LCORL Genes Balance PRC2 Subtype Activities.
Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas.
Armadillo repeat containing 12 promotes neuroblastoma progression through interaction with retinoblastoma binding protein 4.
Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation.
EZHIP/CXorf67 mimics K27M mutated oncohistones and functions as an intrinsic inhibitor of PRC2 function in aggressive posterior fossa ependymoma.
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein interaction landscape of breast cancer.
Identification and functional characterization of transcriptional activators in human cells.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
EZH2 enhances proliferation and migration of trophoblast cell lines by blocking GADD45A-mediated p38/MAPK signaling pathway.
The Disordered EZH2 Loop: Atomic Level Characterization by (1)H(N)- and (1)H(α)-Detected NMR Approaches, Interaction with the Long Noncoding HOTAIR RNA.
PRC2, Chromatin Regulation, and Human Disease: Insights From Molecular Structure and Function.
SNIP1 and PRC2 coordinate cell fates of neural progenitors during brain development.
Multimodal cell maps as a foundation for structural and functional genomics.
Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1.
Mammalian homologues of the Polycomb-group gene Enhancer of zeste mediate gene silencing in Drosophila heterochromatin and at S. cerevisiae telomeres.
PRC2 recruits DNA methyltransferases
Polycomb Repressive Complex 2 (PRC2) Is recruited to chromatin
PRC2 trimethylates histone H3 at lysine-27
DNMT1,3A,3B:PRC2 methylates cytosine and histone H3
PRC2 methylates histones and DNA
PRC2-EZH2 trimethylates nucleosomes associated with CDKN2A promoter
E2F1/2/3 stimulates EZH2 transcription
Formation of PRC2-EZH2 complex
PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)
E2F6:TFDP1:EPC1 binds the PRC2 complex
Activation of Latent HCMV Genome
Latent Transcriptinally Repressed HCMV Genome
The GSDME gene promoter is hypermethylated
PRC2 (EZH2) core complex binds CDH1 gene promoter
PRC2 (EZH2) core complex methylates nucleosomes at CDH1 gene promoter
PRC2(EZH2) core binding to CD274 gene promoter
Trimethylation of CD274 gene promoter by EZH2
Author Correction: An oncogene-tumor suppressor cascade drives metastatic prostate cancer by coordinately activating Ras and nuclear factor-κB.
Author Correction: EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer.
Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.
Histone methyltransferase enhancer of zeste homolog 2 regulates Schwann cell differentiation.
Jarid2/Jumonji coordinates control of PRC2 enzymatic activity and target gene occupancy in pluripotent cells.
The primary microRNA-208b interacts with Polycomb-group protein, Ezh2, to regulate gene expression in the heart.
Ezh2, the histone methyltransferase of PRC2, regulates the balance between self-renewal and differentiation in the cerebral cortex.
Genome-wide survey by ChIP-seq reveals YY1 regulation of lincRNAs in skeletal myogenesis.
Genome-wide identification of polycomb-associated RNAs by RIP-seq.
Linc-YY1 promotes myogenic differentiation and muscle regeneration through an interaction with the transcription factor YY1.
Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.
Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons.
YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus.
Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement.
Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2.
lincRNAs act in the circuitry controlling pluripotency and differentiation.
Histone methyltransferase EZH2 is transcriptionally induced by estradiol as well as estrogenic endocrine disruptors bisphenol-A and diethylstilbestrol.
STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance of GATA3 expression in T helper type 2 cells.
Consequences of the depletion of zygotic and embryonic enhancer of zeste 2 during preimplantation mouse development.
Modified Adenovirus Reduces De Novo Peritoneal Adhesions in Rats and Limits Off-Target Transfection. Role of EZH2 in Adhesion Formation.
Accumulation of malignant renal stem cells is associated with epigenetic changes in normal renal progenitor genes.
The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy.