Gene Ontology annotation through association of InterPro records with GO terms.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods.
Identification and characterization of novel isoforms of COP I subunits
Gamma-COP appendage domain -- structure and function
COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport
A genetic screen in Drosophila reveals an unexpected role for the KIP1 ubiquitination-promoting complex in male fertility.
Combined immunodeficiency due to a mutation in the γ1 subunit of the coat protein I complex.
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Identified COPG1 K652E mutation causing immunodeficiency 128 (IMD128). The mutation impairs KDELR association and retrograde retrieval of KDEL-bearing chaperones, causing ER stress and immune defects.
"The mutation disrupts COPI binding to the KDEL receptor and impairs the retrieval of KDEL-bearing chaperones from the Golgi to the ER"
Active ARF recruits coatomer
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex
ARFGAPs stimulate ARF GTPase activity
ERGIC-to-Golgi vesicles bind dynein:dynactin
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle
Active ARF recruits coatomer to the Golgi
ARFGAP, cargo, vSNARES and p24 proteins bind COPI vesicles at Golgi
ARFGAPs stimulate ARF GTPase activity at the Golgi membrane
Retrograde vesicle is tethered at the ER by the NRZ complex and t-SNAREs
Retrograde COPI vesicles bind kinesin and microtubules
COPI vesicle uncoating at the ER
Deep research on COPG1 function (Falcon Edison Scientific Literature)
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Comprehensive review of COPG1 function including COPI architecture, ARF1-dependent membrane recruitment, cargo recognition via dilysine motifs, KDEL receptor interaction, and disease associations.
Cyberian deep research on COPG1 function