coq4 (O94453, SPAC1687.12c) review notes

Sources

No deep-research provider output is available (no provider API keys in this
environment). The review rests on the UniProt record (HAMAP MF_03111) and the cached
literature; PMID:24911838 was read in full, PMID:38295803 is abstract-only.

Literature

• Deletion abolishes CoQ10 PMID:24911838
• Human COQ4 complements PMID:24911838
• COQ4 is the C1 oxidative decarboxylase (human/yeast proteins in bacterial hosts)
  PMID:38295803
• No S. pombe enzymology.

Audit decisions (2026-11)

• GO:0016831 carboxy-lyase activity changed from TOO_GENERAL to MODIFY -> GO:0120539,
  matching the S. cerevisiae COQ4 review (human COQ4 uses KEEP_AS_NON_CORE with the same
  replacement listed; flagged as a sibling inconsistency for the coordinator).
• Truncated UniProt FUNCTION and CATALYTIC ACTIVITY quotes completed.
• Core function GO:0120539 agrees with the module annoton. The PomBase GO-CAM assigns the
  C1 hydroxylation to coq6; PMID:38295803 assigns both C1 reactions to COQ4.