Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

Gene Ontology annotation based on curation of immunofluorescence data

Gene Ontology annotation based on curation of intracellular localizations of expressed fusion proteins

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells.

Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis.

Roles of the mammalian cytosolic cysteine desulfurase, ISCS, and scaffold protein, ISCU, in iron-sulfur cluster assembly.

Characterization of the human HSC20, an unusual DnaJ type III protein, involved in iron-sulfur cluster biogenesis.

Mammalian frataxin - an essential function for cellular viability through an interaction with a preformed ISCU/NFS1/ISD11 iron-sulfur assembly complex.

Mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation stabilizes ISCU protein - implications for iron metabolism.

Human mitochondrial chaperone (mtHSP70) and cysteine desulfurase (NFS1) bind preferentially to the disordered conformation, whereas co-chaperone (HSC20) binds to the structured conformation of the iron-sulfur cluster scaffold protein (ISCU).

Cochaperone binding to LYR motifs confers specificity of iron sulfur cluster delivery.

Human frataxin activates Fe-S cluster biosynthesis by facilitating sulfur transfer chemistry.

Mitochondrial Hspa9/Mortalin regulates erythroid differentiation via iron-sulfur cluster assembly.

Architecture of the Human Mitochondrial Iron-Sulfur Cluster Assembly Machinery.

Structure and functional dynamics of the mitochondrial Fe/S cluster synthesis complex.

Zinc(II) binding on human wild-type ISCU and Met140 variants modulates NFS1 desulfurase activity.

Structure of the human frataxin-bound iron-sulfur cluster assembly complex provides insight into its activation mechanism.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

N-terminal tyrosine of ISCU2 triggers [2Fe-2S] cluster synthesis by ISCU2 dimerization.

Mechanism and structural dynamics of sulfur transfer during de novo [2Fe-2S] cluster assembly on ISCU2.

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU.

Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer.

Large-scale mapping of human protein-protein interactions by mass spectrometry.

A proteome-scale map of the human interactome network.

Disease-Causing SDHAF1 Mutations Impair Transfer of Fe-S Clusters to SDHB.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.

A reference map of the human binary protein interactome.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

A central chaperone-like role for 14-3-3 proteins in human cells.

Multimodal cell maps as a foundation for structural and functional genomics.

FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster

Frataxin binds iron

nsp12 acquires Fe-S cluster cofactors

Transfer of Fe-S clusters to SDHB

2Fe-2S is inserted in UQCRFS1

Deep research report on ISCU