Gene Ontology annotation through association of InterPro records with GO terms.
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity.
Annotation inferences using phylogenetic trees
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara.
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
Combined Automated Annotation using Multiple IEA Methods.
Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin1, a novel Myc interacting protein.
Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN.
Identification of Mad as a repressor of the human telomerase (hTERT) gene.
Small-molecule antagonists of Myc/Max dimerization inhibit Myc-induced transformation of chicken embryo fibroblasts.
Yaf2 inhibits Myc biological function.
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7.
PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
A structure-based model of the c-Myc/Bin1 protein interaction shows alternative splicing of Bin1 and c-Myc phosphorylation are key binding determinants.
Identification of a novel c-Myc protein interactor, JPO2, with transforming activity in medulloblastoma cells.
Targeting of Miz-1 is essential for Myc-mediated apoptosis.
Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation.
Myc stabilization in response to estrogen and phospholipase D in MCF-7 breast cancer cells.
HPV-18 E7 conjugates to c-Myc and mediates its transcriptional activity.
SNIP1 is a candidate modifier of the transcriptional activity of c-Myc on E box-dependent target genes.
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach.
HIF-2alpha promotes hypoxic cell proliferation by enhancing c-myc transcriptional activity.
Inhibition of c-Myc activity by ribosomal protein L11.
CIP2A inhibits PP2A in human malignancies.
Fbw7 and Usp28 regulate myc protein stability in response to DNA damage.
Epstein-Barr virus nuclear antigen 3C interacts with and enhances the stability of the c-Myc oncoprotein.
c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor.
Adenovirus E1A targets p400 to induce the cellular oncoprotein Myc.
Characterizing proteins and their interactions in cells and tissues using the in situ proximity ligation assay.
AP4 encodes a c-MYC-inducible repressor of p21.
Miz1 and HectH9 regulate the stability of the checkpoint protein, TopBP1.
The parafibromin tumor suppressor protein inhibits cell proliferation by repression of the c-myc proto-oncogene.
The Axin1 scaffold protein promotes formation of a degradation complex for c-Myc.
A ribosomal protein L23-nucleophosmin circuit coordinates Mizl function with cell growth.
Dnmt3/transcription factor interactions as crucial players in targeted DNA methylation.
A comprehensive resource of interacting protein regions for refining human transcription factor networks.
Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses.
Myc protein is stabilized by suppression of a novel E3 ligase complex in cancer cells.
Myc-nick: a cytoplasmic cleavage product of Myc that promotes alpha-tubulin acetylation and cell differentiation.
Noninvasive molecular imaging of c-Myc activation in living mice.
A human MAP kinase interactome.
NEMO stabilizes c-Myc through direct interaction in the nucleus.
Proteomic profiling of Myc-associated proteins.
TIP110/p110nrb/SART3/p110 regulation of hematopoiesis through CMYC.
IκB kinases increase Myc protein stability and enhance progression of breast cancer cells.
Sirt1 deacetylates c-Myc and promotes c-Myc/Max association.
Toward an understanding of the protein interaction network of the human liver.
A systematic screen for CDK4/6 substrates links FOXM1 phosphorylation to senescence suppression in cancer cells.
The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.
A Y2H-seq approach defines the human protein methyltransferase interactome.
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability.
Structural and biochemical studies of SLIP1-SLBP identify DBP5 and eIF3g as SLIP1-binding proteins.
Deterministic direct reprogramming of somatic cells to pluripotency.
Sin3b interacts with Myc and decreases Myc levels.
AMBRA1 links autophagy to cell proliferation and tumorigenesis by promoting c-Myc dephosphorylation and degradation.
Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
The Nucleolar Protein GLTSCR2 Is an Upstream Negative Regulator of the Oncogenic Nucleophosmin-MYC Axis.
Small Molecule Inhibition of ERK Dimerization Prevents Tumorigenesis by RAS-ERK Pathway Oncogenes.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity.
The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.
A High-Density Map for Navigating the Human Polycomb Complexome.
Primate-specific miR-515 family members inhibit key genes in human trophoblast differentiation and are upregulated in preeclampsia.
The pseudophosphatase STYX targets the F-box of FBXW7 and inhibits SCFFBXW7 function.
Transforming Growth Factor β-Induced Proliferative Arrest Mediated by TRIM26-Dependent TAF7 Degradation and Its Antagonism by MYC.
Integrin alpha x stimulates cancer angiogenesis through PI3K/Akt signaling-mediated VEGFR2/VEGF-A overexpression in blood vessel endothelial cells.
A reference map of the human binary protein interactome.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity.
Proteome-scale mapping of binding sites in the unstructured regions of the human proteome.
Human transcription factor protein interaction networks.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
Large-scale phosphomimetic screening identifies phospho-modulated motif-based protein interactions.
Ribogenesis boosts controlled by HEATR1-MYC interplay promote transition into brain tumour growth.
Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor.
Association of Myc with the zinc-finger protein Miz-1 defines a novel pathway for gene regulation by Myc.
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins.
Coordinated regulation of iron-controlling genes, H-ferritin and IRP2, by c-MYC.
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt.
Gene Ontology annotation based on curation of immunofluorescence data
Overexpression of MYC causes p53-dependent G2 arrest of normal fibroblasts.
Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours.
X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors.
Multiple tumor suppressor pathways negatively regulate telomerase.
Sterol-responsive element-binding protein (SREBP) 2 down-regulates ATP-binding cassette transporter A1 in vascular endothelial cells: a novel role of SREBP in regulating cholesterol metabolism.
ERK1/2 regulates intracellular ATP levels through alpha-enolase expression in cardiomyocytes exposed to ischemic hypoxia and reoxygenation.
The ubiquitin-specific protease USP28 is required for MYC stability.
c-Myc interacts with TRF1/PIN2 and regulates telomere length.
Sulindac suppresses beta-catenin expression in human cancer cells.
Multiple Wnt/ß-catenin responsive enhancers align with the MYC promoter through long-range chromatin loops.
The nucleolar ubiquitin-specific protease USP36 deubiquitinates and stabilizes c-Myc.
MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability.
Mad: a heterodimeric partner for Max that antagonizes Myc transcriptional activity.
BIN1 is a novel MYC-interacting protein with features of a tumour suppressor.
Histamine modulates the expression of c-fos through cyclic AMP production via the H2 receptor in the human promonocytic cell line U937.
MYC trancscription is negatively regulated by SMAD2/3:SMAD4:RBL1:E2F4/5:DP1/2 complex
NOTCH1 stimulates MYC transcription
NOTCH1 PEST domain mutants stimulate MYC transcription
TCF7L1/TCF7L2/LEF1:CTNNB1 promote transcription of the MYC gene
MYC mRNA translation is negatively regulated by miR-34B and C
USP28 deubiquitinates CLSPN and MYC
Expression of STAT3-upregulated nuclear proteins
TFAP2C homodimer binds MYC and KDM5B
TFAP2C homodimer binds the CDKN1A (p21) gene promoter
MYC:MAX binds the CDC25A gene
Estrogen-responsive MYC gene expression
MYC/MYCN bind the ALK gene
MYC binds the NFE2L2 promoter
MYC,MYCN bind MIR9-3 gene locus
Deep research report on MYC