Gene Ontology annotation through association of InterPro records with GO terms
Gene Ontology annotation based on Enzyme Commission mapping
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Gene Ontology annotation based on curation of immunofluorescence data
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining.
Autophosphorylation of the DNA-dependent protein kinase catalytic subunit is required for rejoining of DNA double-strand breaks.
DNA-PK is activated by nucleosomes and phosphorylates H2AX within the nucleosomes in an acetylation-dependent manner.
DNA-PKcs function regulated specifically by protein phosphatase 5.
Phosphorylation and regulation of DNA ligase IV stability by DNA-dependent protein kinase.
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase.
DNA-PK is responsible for enhanced phosphorylation of histone H2AX under hypertonic conditions.
A role for the HOXB7 homeodomain protein in DNA repair.
A YY1-INO80 complex regulates genomic stability through homologous recombination-based repair.
The catalytic subunit of DNA-dependent protein kinase regulates proliferation, telomere length, and genomic stability in human somatic cells.
Purification of proteins associated with specific genomic Loci.
A role of DNA-PK for the metabolic gene regulation in response to insulin.
Ku proteins function as corepressors to regulate farnesoid X receptor-mediated gene expression.
Defining the membrane proteome of NK cells.
Crystal structure of DNA-PKcs reveals a large open-ring cradle comprised of HEAT repeats.
Aire's partners in the molecular control of immunological tolerance.
Ku is a 5'-dRP/AP lyase that excises nucleotide damage near broken ends.
Regulation of DNA-dependent protein kinase by protein kinase CK2 in human glioblastoma cells.
Mechanistic rationale for inhibition of poly(ADP-ribose) polymerase in ETS gene fusion-positive prostate cancer.
DNA-PK-dependent RPA2 hyperphosphorylation facilitates DNA repair and suppresses sister chromatid exchange.
Systematic analysis of protein pools, isoforms, and modifications affecting turnover and subcellular localization.
Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-γ and p53 signaling.
Artemis C-terminal region facilitates V(D)J recombination through its interactions with DNA Ligase IV and DNA-PKcs.
Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.
The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts.
Functional interaction of BRCA1/ATM-associated BAAT1 with the DNA-PK catalytic subunit.
DNA-dependent protein kinase catalytic subunit (DNA-PKcs)-SIN1 association mediates ultraviolet B (UVB)-induced Akt Ser-473 phosphorylation and skin cell survival.
DNA damage triggers Golgi dispersal via DNA-PK and GOLPH3.
Enhancer activation requires trans-recruitment of a mega transcription factor complex.
TNKS1BP1 functions in DNA double-strand break repair though facilitating DNA-PKcs autophosphorylation dependent on PARP-1.
DNA-dependent protein kinase (DNA-PK) permits vascular smooth muscle cell proliferation through phosphorylation of the orphan nuclear receptor NOR1.
XLS (c9orf142) is a new component of mammalian DNA double-stranded break repair.
DNA-PKcs-Mediated Transcriptional Regulation Drives Prostate Cancer Progression and Metastasis.
Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation.
A human interactome in three quantitative dimensions organized by stoichiometries and abundances.
PICT-1 is a key nucleolar sensor in DNA damage response signaling that regulates apoptosis through the RPL11-MDM2-p53 pathway.
HEXIM1 and NEAT1 Long Non-coding RNA Form a Multi-subunit Complex that Regulates DNA-Mediated Innate Immune Response.
Cryo-EM structure of human DNA-PK holoenzyme.
The Histone Chaperones ASF1 and CAF-1 Promote MMS22L-TONSL-Mediated Rad51 Loading onto ssDNA during Homologous Recombination in Human Cells.
DNA-PKcs has KU-dependent function in rRNA processing and haematopoiesis.
TIP60 K430 SUMOylation attenuates its interaction with DNA-PKcs in S-phase cells: Facilitating homologous recombination and emerging target for cancer therapy.
DNA-PK deficiency potentiates cGAS-mediated antiviral innate immunity.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
Cryo-EM of NHEJ supercomplexes provides insights into DNA repair.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS.
DNA-dependent protein kinase catalytic subunit: a relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product.
DNA-dependent protein kinase interacts with antigen receptor response element binding proteins NF90 and NF45.
DNA-PK binds microbial dsDNA
DCLRE1C binds PRKDC:XRCC5:XRCC6 at DNA DSBs
PRKDC phosphorylates DCLRE1C at DNA DSBs
POLL or POLM extends aligned DNA DSB ends to fill gaps
DCLRE1C (ARTEMIS) processes DNA DSB ends
Nonhomologous End-Joining (NHEJ)
XRCC4:LIG4, NHEJ1 and POLL or POLM bind DNA DSBs in NHEJ
DNA-PKcs autophosphorylates
TDP1 and TDP2 process unligatable DSB ends
XRCC4:LIG4 ligates DNA DSB ends during NHEJ
Association of DNA-PKcs with Ku-bound ends of DNA double-strand breaks - synapsis
RNF144A binds PRKDC and Ubiquitin:UBE2L3
RNF144A polyubiquitinates PRKDC
Hairpin opening and overhang processing by an Artemis/DNA-dependent protein kinase complex in nonhomologous end joining and V(D)J recombination.
A DNA-PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining.
PRKDC mutations in a SCID patient with profound neurological abnormalities.
DNA-PK is a DNA sensor for IRF-3-dependent innate immunity.
Structure of an activated DNA-PK and its implications for NHEJ.
Structural basis of long-range to short-range synaptic transition in NHEJ.
Efferocytosis induces macrophage proliferation to help resolve tissue injury.