Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Ataxin-3, the MJD1 gene product, interacts with the two human homologs of yeast DNA repair protein RAD23, HHR23A and HHR23B.
Ataxin-3 is a histone-binding protein with two independent transcriptional corepressor activities.
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Ataxin-3 binds histones and interacts with the histone acetyltransferase coactivators CBP, p300 and PCAF, repressing coactivator-dependent transcription; this is the source for the histone-binding transcriptional-regulator role stated in the description.
"ataxin-3, interacts with the major histone acetyltransferases cAMP-response-element binding protein (CREB)-binding protein, p300, and p300/CREB-binding protein-associated factor and inhibits transcription by these coactivators"
An arginine/lysine-rich motif is crucial for VCP/p97-mediated modulation of ataxin-3 fibrillogenesis.
A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.
Regulation of retrotranslocation by p97-associated deubiquitinating enzyme ataxin-3.
Josephin domain-containing proteins from a variety of species are active de-ubiquitination enzymes.
Absence of ataxin-3 leads to cytoskeletal disorganization and increased cell death.
Co-chaperone HSJ1a dually regulates the proteasomal degradation of ataxin-3.
Valosin-containing protein (VCP/p97) is an activator of wild-type ataxin-3.
Ataxin-3 is a multivalent ligand for the parkin Ubl domain.
A deubiquitinase negatively regulates retro-translocation of nonubiquitinated substrates.
CDK5 protects from caspase-induced Ataxin-3 cleavage and neurodegeneration.
Polyglutamine tracts regulate beclin 1-dependent autophagy.
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Ataxin-3 knockdown impairs autophagosome biogenesis and lowers beclin 1 levels, the basis for the BECN1/starvation-autophagy clause of the description.
"The decreased autophagosome biogenesis following ataxin-3 knockdown was associated with lower beclin 1 levels"
Physiological and pathophysiological characteristics of ataxin-3 isoforms.
Mutant huntingtin impairs PNKP and ATXN3, disrupting DNA repair and transcription.
Ataxin-3 Links NOD2 and TLR2 Mediated Innate Immune Sensing and Metabolism in Myeloid Cells.
Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis.
Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.
Amino Acids Enhance Polyubiquitination of Rheb and Its Binding to mTORC1 by Blocking Lysosomal ATXN3 Deubiquitinase Activity.
ATXN3 controls DNA replication and transcription by regulating chromatin structure.
Trinucleotide expansion within the MJD1 gene presents clinically as spinocerebellar ataxia and occurs most frequently in German SCA patients.
Machado-Joseph disease gene product is a cytoplasmic protein widely expressed in brain.
Ataxin-3 is transported into the nucleus and associates with the nuclear matrix.
ATXN3 family cleave Ub chains
ATXN3 deubiquitinates polyUb-PARK2
FOXO4:ATXN3 binds SOD2 gene promoter