Gene Ontology annotation through association of InterPro records with GO terms
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
Hoxa2 downregulates Six2 in the neural crest-derived mesenchyme.
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Hoxa2 binds a 0.9 kb Six2 promoter fragment and Six2 is upregulated in Hoxa2 mutants, identifying Six2 as a directly repressed target in second-arch mesenchyme.
"Hoxa2 regulation of Six2 is confined to a 0.9 kb fragment of the Six2 promoter and that Hoxa2 binds to this promoter region"
Rostral hindbrain patterning involves the direct activation of a Krox20 transcriptional enhancer by Hox/Pbx and Meis factors.
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Hox/Pbx and Meis binding sites in Krox20 element C mediate direct transcriptional activation in rhombomere 3.
"Krox20 is under the direct transcriptional control of both Meis (presumably Meis2) and Hox/Pbx factors in r3"
Temporal requirement of Hoxa2 in cranial neural crest skeletal morphogenesis.
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Hoxa2 is required cell-autonomously in cranial neural crest, including after migration, for second-arch skeletal identity.
"Hoxa2 is selectively required in cranial neural crest cells (NCCs)"
Distinct effects of Hoxa2 overexpression in cranial neural crest populations reveal that the mammalian hyomandibular-ceratohyal boundary maps within the styloid process.
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Ectopic Hoxa2 in Hox-negative cranial neural crest transforms first-arch derivatives into second-arch-like structures.
"ectopic Hoxa2 expression is sufficient for the morphological and molecular transformation of the first PA (PA1) CNCC derivatives into the second PA (PA2)-like structures"
Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord.
Hoxa-2 mutant mice exhibit homeotic transformation of skeletal elements derived from cranial neural crest.
A homeotic transformation is generated in the rostral branchial region of the head by disruption of Hoxa-2, which acts as a selector gene.
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
UniProt record for human HOXA2 (O43364)
UniProt record for mouse Hoxa2 (P31245)
HOXA2: donkey-human sequence comparison
Experimental GO annotations of human and mouse HOXA2 orthologs (QuickGO)