Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Combined Automated Annotation using Multiple IEA Methods
Formation of CD4:Nef:AP-2 Complex:v-ATPase Complex
Internalization of the CD4:Nef:AP-2 Complex:v-ATPase Complex
Axonal transport of NGF:Trk complexes
Formation of CD8:Nef:AP-2 Complex:v-ATPase Complex
Internalization of the CD8:Nef:AP-2 Complex:v-ATPase Complex
Uncoating of clathrin-coated vesicles and fusion with endosomes
Recruitment of clathrin coated vesicle by Ii
Internalization of MHC II:Ii clathrin coated vesicle
L1 binds to AP-2 Clathrin complex
Transport of L1 into endosomes
Clathrin internalises EPH:EFN complexes
Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites
Reinsertion of L1 into the plasma membrane
Phosphorylation of L1 by ERK
p-DVL2 recruits AP-2 and beta-arrestin 2 to promote clathrin-mediated endocytosis
WNT5A:FZD4 is endocytosed
Formation of clathrin coated vesicle
PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome
PCSK9:LDLR bind to Clathrin
Degradation of PCSK9:LDLR:Clathrin-coated vesicle
VLDLR:PCSK9:Clathrin-coated vesicle translocates from the plasma membrane to lysosomal membrane
VLDLR:PCSK9 binds Clathrin-coated vesicles
Recruitment of AP-2 complex and clathrin
AAK1 phosphorylates AP-2 mu subunit at T156
FCHo proteins bind nascent clathrin-coated pit
AP-2 directly binds some endocytic cargo
Epsin family proteins bind ubiquitinated cargo
ARBB recruits GPCRs into clathrin-coated pits
F- and N- BAR domain proteins bind the clathrin-coated pit
CLASP proteins and cargo are recruited to the nascent clathrin-coated pit
Clathrin recruits PIK3C2A
Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2
SNX9 recruits components of the actin polymerizing machinery
BAR domain proteins recruit dynamin
SYNJ hydrolyze PI(4,5)P2 to PI(4)P
Endophilins recruit synaptojanins to the clathrin-coated pit
HSPA8-mediated ATP hydrolysis promotes vesicle uncoating
Clathrin recruits auxilins to the clathrin-coated vesicle
Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle
Dynamin-mediated GTP hydrolysis promotes vesicle scission
Dissociation of clathrin-associated proteins
Dissociation of AAK1 and dephosphorylation of AP-2 mu2
RAB5 and GAPVD1 bind AP-2
Initial binding of AP-2 and clathrin to PI(4,5)P2
A structural explanation for the binding of endocytic dileucine motifs by the AP2 complex.
Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3.
CCDC32 collaborates with the membrane to assemble the AP-2 clathrin adaptor complex.
AAGAB Controls AP2 Adaptor Assembly in Clathrin-Mediated Endocytosis.
Ap2s1 mutation causes hypercalcaemia in mice and impairs interaction between calcium-sensing receptor and adaptor protein-2.
N-ethyl-N-nitrosourea-Induced Adaptor Protein 2 Sigma Subunit 1 (Ap2s1) Mutations Establish Ap2s1 Loss-of-Function Mice.
Adaptor protein-2 sigma subunit mutations causing familial hypocalciuric hypercalcaemia type 3 (FHH3) demonstrate genotype-phenotype correlations, codon bias and dominant-negative effects.
Large-scale exome datasets reveal a new class of adaptor-related protein complex 2 sigma subunit (AP2σ) mutations, located at the interface with the AP2 alpha subunit, that impair calcium-sensing receptor signalling.
A calcium-sensing receptor dileucine motif directs internalization to spatially distinct endosomal signaling pathways.
A conserved clathrin assembly motif essential for synaptic vesicle endocytosis.
The mu2 subunit of the clathrin adaptor AP-2 binds to FDNPVY and YppØ sorting signals at distinct sites.
Molecular architecture and functional model of the endocytic AP2 complex.
Weak Molecular Interactions in Clathrin-Mediated Endocytosis.
Analysis of the AP-2 adaptor complex and cargo during clathrin-mediated endocytosis.
CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.
Endocytic Adaptor Proteins in Health and Disease: Lessons from Model Organisms and Human Mutations.
Clathrin coat construction in endocytosis.
A genome-wide atlas of co-essential modules assigns function to uncharacterized genes.
AP2S1 regulates APP degradation through late endosome-lysosome fusion in cells and APP/PS1 mice.
The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows.
A proteome-scale map of the human interactome network.
Architecture of the human interactome defines protein communities and disease networks.
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
A reference map of the human binary protein interactome.
Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.
OpenCell: Endogenous tagging for the cartography of human cellular organization.
Multimodal cell maps as a foundation for structural and functional genomics.
UniProtKB P53680 (AP2S1_HUMAN) curated record
AP2S1 sigma2 dileucine-pocket residue check and sigma-paralogue alignment
Affinage mechanistic annotation for AP2S1 (human)