Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Combined Automated Annotation using Multiple IEA Methods

Apelin, the natural ligand of the orphan receptor APJ, is abundantly secreted in the colostrum.

Physiological role of a novel neuropeptide, apelin, and its receptor in the rat brain.

The novel peptide apelin lowers blood pressure via a nitric oxide-dependent mechanism.

Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase.

Apelin, a potent diuretic neuropeptide counteracting vasopressin actions through inhibition of vasopressin neuron activity and vasopressin release.

Impaired heart contractility in Apelin gene-deficient mice associated with aging and pressure overload.

Hypoxia-induced apelin expression regulates endothelial cell proliferation and regenerative angiogenesis.

Apelin stimulates glucose utilization in normal and obese insulin-resistant mice.

Endogenous regulation of cardiovascular function by apelin-APJ.

APJ acts as a dual receptor in cardiac hypertrophy.

An endothelial apelin-FGF link mediated by miR-424 and miR-503 is disrupted in pulmonary arterial hypertension.

Preferential apelin-13 production by the proprotein convertase PCSK3 is implicated in obesity.

Characterization of apela, a novel endogenous ligand of apelin receptor, in the adult heart.

Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.

Agonist-induced internalization and desensitization of the apelin receptor.

Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.

Alternative Progenitor Cells Compensate to Rebuild the Coronary Vasculature in Elabela- and Apj-Deficient Hearts.

Structure-based design of non-hypertrophic apelin receptor modulator.

Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor.

Apelin receptor binds to apelin

Liganded Gi-activating GPCR acts as a GEF for Gi

The Ligand:GPCR:Gi complex dissociates

Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi

APLN bioinformatics: apelin-13/-17 conservation, the ACE2 cleavage motif, and WITH/FROM resolution

Affinage mechanistic annotation for APLN (human)

UniProtKB entry Q9ULZ1 (APEL_HUMAN), apelin