Gene Ontology annotation through association of InterPro records with GO terms

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on curation of immunofluorescence data

Automatic assignment of GO terms using logical inference, based on on inter-ontology links

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

UniProt entry O75489 (NDUS3_HUMAN)

Human complex I defects can be resolved by monoclonal antibody analysis into distinct subunit assembly patterns.

The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

Mutant NDUFS3 subunit of mitochondrial complex I causes Leigh syndrome.

Structural organization of mitochondrial human complex I: role of the ND4 and ND5 mitochondria-encoded subunits and interaction with prohibitin.

Coupling mitochondrial respiratory chain to cell death: an essential role of mitochondrial complex I in the interferon-beta and retinoic acid-induced cancer cell death.

Identification of mitochondrial complex I assembly intermediates by tracing tagged NDUFS3 demonstrates the entry point of mitochondrial subunits.

Subunits of mitochondrial complex I exist as part of matrix- and membrane-associated subcomplexes in living cells.

Mutations in NDUFAF3 (C3ORF60), encoding an NDUFAF4 (C6ORF66)-interacting complex I assembly protein, cause fatal neonatal mitochondrial disease.

LC-MS/MS as an alternative for SDS-PAGE in blue native analysis of protein complexes.

DJ-1 binds to mitochondrial complex I and maintains its activity.

NDUFB7 and NDUFA8 are located at the intermembrane surface of complex I.

Quantitative proteomic analysis of human substantia nigra in Alzheimer's disease, Huntington's disease and Multiple sclerosis.

TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex.

Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function.

Architecture of the human interactome defines protein communities and disease networks.

Architecture of Human Mitochondrial Respiratory Megacomplex I(2)III(2)IV(2).

Assembly of mammalian oxidative phosphorylation complexes I-V and supercomplexes.

A Novel NDUFS3 mutation in a Chinese patient with severe Leigh syndrome.

Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

A reference map of the human binary protein interactome.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

Quantitative high-confidence human mitochondrial proteome and its dynamics in cellular context.

cDNA sequence and chromosomal localization of the remaining three human nuclear encoded iron sulphur protein (IP) subunits of complex I: the human IP fraction is completed.

cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed.

Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2

Intermediate 1 binds HP subcomplex to form Intermediate 2

Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex

Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex

The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I

ND4, ND5 bind the 550kDa complex to form the 815kDa complex

The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex

IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1

NDUF subunits bind to form the IP subcomplex

CLPXP binds mitochondrial matrix proteins

CLPXP degrades mitochondrial matrix proteins