Gene Ontology annotation through association of InterPro records with GO terms
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic assignment of GO terms using logical inference, based on on inter-ontology links
Automatic Gene Ontology annotation based on Rhea mapping
Electronic Gene Ontology annotations created by ARBA machine learning models
Combined Automated Annotation using Multiple IEA Methods
RGD ISO annotations to rat from other mammalian species
Falcon (Edison Scientific) deep research report on rat Mapk1 (ERK2), UniProt P63086
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Mapk1 (UniProt P63086) is ERK2, the terminal serine/threonine kinase of the
canonical RAS-RAF-MEK-ERK cascade, distinct from Mapk3/ERK1.
"Mapk1 encodes ERK2**, a serine/threonine MAP kinase in the canonical RAS→RAF→MEK→ERK cascade"
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ERK1/2 are the terminal kinases of the canonical RAS-RAF-MEK-ERK cascade
downstream of many membrane receptors, with outputs including proliferation,
differentiation, EMT, senescence, and cell death depending on signal strength,
duration, context, and spatial localization.
"ERK1/2 (MAPK3/MAPK1) are described as **terminal kinases** in the canonical **RAS→RAF→MEK→ERK** cascade downstream of many membrane receptors, with outputs that include proliferation, differentiation, epithelial–mesenchymal transition (EMT), senescence, and cell death"
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ERK2 is a serine/threonine kinase; in the rat IMCD phosphoproteomic resource
ERK-family proteins are annotated under a serine/threonine kinase domain
category.
"ERK family proteins are annotated under a **serine/threonine kinase domain category**"
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ERK2 is activated by dual phosphorylation of the TEY activation-loop motif
(T179/Y185 in the rat UniProt-mapped table), directly observed for rat
Mapk1/ERK2.
"Dual phosphorylation in the TEY activation segment region** is directly observed for rat Mapk1/ERK2"
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In native rat IMCD cells, MEK2 (Map2k2) activity is placed upstream of Mapk1
phosphorylation, and EGF activates the canonical MAPK pathway in this rat
tissue context.
"the same rat IMCD network links **Map2k2 (MEK2)** activity to Mapk1 phosphorylation"
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Pathway enrichment in native rat IMCD cells confirms engagement of RAF-MEK-ERK
signaling after EGF stimulation.
"pathway enrichment confirms engagement of **RAF–MEK–ERK signaling**"
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ERK1/2 phosphorylate substrates containing a Ser/Thr-Pro consensus motif.
"ERK1/2 substrates contain a **Ser/Thr‑Pro** consensus"
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ERK2 kinase activity uses ATP; an in vitro kinase assay with active
TEY-phosphorylated ERK2 and an ATPgammaS analog was used to test substrate
phosphorylation.
"an in vitro kinase assay with active TEY-phosphorylated ERK2 and an ATPγS analog"
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ERK2 localization is a key regulatory feature: transcriptional outcomes often
require nuclear ERK, and PEA-15 binds ERK, contains a nuclear export sequence,
and can prevent nuclear accumulation of ERK.
"PEA‑15** binds ERK and (i) contains a nuclear export sequence, and (ii) can **prevent nuclear accumulation** of ERK"
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ERK2 signaling is organized via membrane/cytoplasmic scaffolds; the NHE1/Slc9a1
Na+/H+ exchanger can act as a membrane scaffold for ERK2, which phosphorylates
NHE1.
"NHE1/Slc9a1** can act as a **membrane scaffold** for ERK2"
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ERK2 is linked to translation-control nodes (e.g., Eif4ebp1 and Eef2k) in the
rat IMCD EGF network.
"ERK2 is also linked to translation-control nodes including Eif4ebp1 and Eef2k"
Metabotropic glutamate receptor subtypes 1 and 5 are activators of extracellular signal-regulated kinase signaling required for inflammatory pain in mice.
Beta-amyloid activates the mitogen-activated protein kinase cascade via hippocampal alpha7 nicotinic acetylcholine receptors: In vitro and in vivo mechanisms related to Alzheimer's disease.
Defective mitogen-activated protein kinase (ERK2) signaling in gastric mucosa of portal hypertensive rats: potential therapeutic implications.
Cyclic changes in estradiol regulate synaptic plasticity through the MAP kinase pathway.
Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate.
Prostaglandin E2 transactivates EGF receptor: a novel mechanism for promoting colon cancer growth and gastrointestinal hypertrophy.
The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2.
1alpha,25-dihydroxyvitamin D(3) and 24R,25-dihydroxyvitamin D(3) modulate growth plate chondrocyte physiology via protein kinase C-dependent phosphorylation of extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase.
Acrolein activates mitogen-activated protein kinase signal transduction pathways in rat vascular smooth muscle cells.
DOC1R: a MAP kinase substrate that control microtubule organization of metaphase II mouse oocytes.
Angiotensin II-induced ERK1/ERK2 activation and protein synthesis are redox-dependent in glomerular mesangial cells.
The indazole derivative YD-3 inhibits thrombin-induced vascular smooth muscle cell proliferation and attenuates intimal thickening after balloon injury.
Caveolin-2 regulation of the cell cycle in response to insulin in Hirc-B fibroblast cells.
17-Beta estradiol rapidly enhances extracellular signal-regulated kinase 2 phosphorylation in the rat brain.
Reactive oxygen species and ERK 1/2 mediate monocyte chemotactic protein-1-stimulated smooth muscle cell migration.
cGMP-dependent protein kinase type I inhibits TAB1-p38 mitogen-activated protein kinase apoptosis signaling in cardiac myocytes.
Alterations in mammalian target of rapamycin signaling pathways after traumatic brain injury.
Growth factor-induced MAPK network topology shapes Erk response determining PC-12 cell fate.
MAPK-ERK activation in kidney of male rats chronically fed ochratoxin A at a dose causing a significant incidence of renal carcinoma.
Dopamine promotes striatal neuronal apoptotic death via ERK signaling cascades.
Signaling pathway adaptations and novel protein kinase A substrates related to behavioral sensitization to cocaine.
LysRS serves as a key signaling molecule in the immune response by regulating gene expression.
The ERK signaling cascade--views from different subcellular compartments.
Phosphorylation of DCC by ERK2 is facilitated by direct docking of the receptor P1 domain to the kinase.
Ovarian steroid receptors and activated MAPK in the regional decidualization in rats.
Elevated activation of ERK1 and ERK2 accompany enhanced liver injury following alcohol binge in chronically ethanol-fed rats.
Extracellular signal-regulated kinase 2 signaling in the hippocampal dentate gyrus mediates the antidepressant effects of testosterone.
Sex differences in social interaction behaviors in rats are mediated by extracellular signal-regulated kinase 2 expression in the medial prefrontal cortex.
Activation of Nrf2 is required for up-regulation of the π class of glutathione S-transferase in rat primary hepatocytes with L-methionine starvation.
MURC/Cavin-4 facilitates recruitment of ERK to caveolae and concentric cardiac hypertrophy induced by α1-adrenergic receptors.
MAPK1 up-regulates the expression of MALAT1 to promote the proliferation of cardiomyocytes through PI3K/AKT signaling pathway.
Phosphorylation or Mutation of the ERK2 Activation Loop Alters Oligonucleotide Binding.
Desmoplakin maintains gap junctions by inhibiting Ras/MAPK and lysosomal degradation of connexin-43.
ERK2-type mitogen-activated protein kinase (MAPK) and its substrates in postsynaptic density fractions from the rat brain.
Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro.
ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation.
cAMP antagonizes p21ras-directed activation of extracellular signal-regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.
Epidermal growth factor induces phosphorylation of extracellular signal-regulated kinase 2 via multiple pathways.
Insulin-like growth factor-I rapidly activates multiple signal transduction pathways in cultured rat cardiac myocytes.
Immunolocalization of the mitogen-activated protein kinases p42MAPK and JNK1, and their regulatory kinases MEK1 and MEK4, in adult rat central nervous system.
Expression of mitogen-activated protein kinase pathways during postnatal development of rat heart.
Mapk1 (Erk2) phosphorylates ERF