Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
DivIVA is required for polar growth in the MreB-lacking rod-shaped actinomycete Corynebacterium glutamicum.
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DivIVA from B. subtilis localizes to the septum rather than poles when expressed in C. glutamicum
"DivIVA proteins from Bacillus subtilis or Streptococcus pneumoniae, which localized at the septum of C. glutamicum"
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DivIVA proteins show functional divergence between actinomycetes and firmicutes
"This confirmed that DivIVAs from actinomycetes are involved in polarized cell growth"
Control of the cell elongation-division cycle by shuttling of PBP1 protein in Bacillus subtilis.
Features critical for membrane binding revealed by DivIVA crystal structure.
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N-terminal domain forms parallel coiled-coil with membrane-binding loop
"We have determined the crystal structure of the N-terminal (Nt) domain of DivIVA, and show that it forms a parallel coiled-coil"
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Hydrophobic and positively charged residues essential for membrane binding
"exposing hydrophobic and positively charged residues that we show here are essential for membrane binding"
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C-terminal domain forms curved tetramer from two parallel coiled-coils
"A low-resolution crystal structure of the C-terminal (Ct) domain displays a curved tetramer made from two parallel coiled-coils"
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Full-length DivIVA protein is approximately 30 nm long
"The Nt and Ct parts were then merged into a model of the full length, 30 nm long DivIVA protein"
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DivIVA deletion causes filamentous growth in B. subtilis
"DivIVA deletion causes filamentous growth in Bacillus subtilis"
An expanded protein-protein interaction network in Bacillus subtilis reveals a group of hubs: Exploration by an integrative approach.
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DivIVA identified as part of highly connected protein hub group
"A striking feature of the network is a group of highly connected hubs (GoH) linking many different cellular processes"
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Self-interaction detected by yeast two-hybrid
"We have generated a protein-protein interaction network in Bacillus subtilis focused on several essential cellular processes such as cell division"
DivIVA-mediated polar localization of ComN, a posttranscriptional regulator of Bacillus subtilis.
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ComN directly interacts with DivIVA via yeast two-hybrid and GST pulldown
"Yeast two-hybrid and glutathione S-transferase pulldown experiments showed that ComN interacts directly with DivIVA"
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ComN localization to poles and division sites is DivIVA-dependent
"ComN localizes to the division site and cell poles in a DivIVA-dependent fashion"
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DivIVA functions as versatile promoter of bacterial pole differentiation
"Our results underscore the versatility of DivIVA as a promoter of the differentiation of bacterial poles"
Deep research synthesis on DivIVA function
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DivIVA recruits MinJ which positions MinCD at previous division sites
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During sporulation DivIVA shows forespore-biased localization
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DivIVA associates with SpoIIE for compartment-specific sigma-F activation
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DivIVA targets negatively curved membrane regions at poles and septa