TreeGrafter-generated GO annotations
Combined Automated Annotation using Multiple IEA Methods
The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM.
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Human Necl-2/CADM1 is the ligand of CRTAM on NK and CD8+ T cells, and the interaction promotes NK cytotoxicity and NK-mediated tumor rejection.
"CRTAM-Necl-2 interactions promote cytotoxicity of NK cells"
Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule.
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Necl2/CADM1 binds CRTAM, independently confirming the ligand-receptor pair.
"We further show that Necl2 binds Class-I-restricted T-cell-associated molecule (CRTAM)"
SynCAM, a synaptic adhesion molecule that drives synapse assembly.
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SynCAM (CADM1) is a homophilic adhesion molecule at synapses that binds PDZ proteins through its cytoplasmic tail and drives synapse assembly.
"functions as a homophilic cell adhesion molecule at the synapse"
TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer.
UniProt record for donkey CADM1 (A0A9L0IX39)
UniProt record for human CADM1 (Q9BY67)
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Human CADM1 mediates homophilic adhesion and, via CRTAM, NK-cell cytotoxicity.
"Mediates homophilic cell-cell adhesion in a Ca(2+)-independent manner"
CADM1: donkey-human sequence comparison
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The donkey CADM1 extracellular and transmembrane regions are conserved but the cytoplasmic tail is divergent.
"The donkey CADM1 protein matches human CADM1 at 96.38% identity over 387 paired residues."
CADM1 (donkey): benchmark entry vs other products of the same gene
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A0A9L0IX39 is a short-tail alternative product of the donkey CADM1 gene; the gene-centric canonical product A0A9L0IJE9 (473 aa) retains the cytoplasmic tail with the EYFI PDZ-binding motif.
"The gene-centric canonical product is A0A9L0IJE9 (473 aa), which ends in the EYFI PDZ-binding motif."