Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.

Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins.

Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro.

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: oxysterols block transport by binding to Insig.

A proteome-scale map of the human interactome network.

A reference map of the human binary protein interactome.

The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis.

SREBP1A/1C/2 is retained in the endoplasmic reticulum by SCAP:cholesterol:INSIG

SREBP2 (SREBF2) is retained in the endoplasmic reticulum by SCAP:INSIG2:oxysterol

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Insig renders sorting signal in Scap inaccessible to COPII proteins.

Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles.

Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain.

Juxtamembranous aspartic acid in Insig-1 and Insig-2 is required for cholesterol homeostasis.

Sterol-induced degradation of HMG CoA reductase depends on interplay of two Insigs and two ubiquitin ligases, gp78 and Trc8.

Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation.

Ring finger protein 145 (RNF145) is a ubiquitin ligase for sterol-induced degradation of HMG-CoA reductase.

A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols.

PROTEIN STRUCTURE. Crystal structure of a mycobacterial Insig homolog provides insight into how these sensors monitor sterol levels.

Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.

Cloning, human chromosomal assignment, and adipose and hepatic expression of the CL-6/INSIG1 gene.

Gp78, a membrane-anchored ubiquitin ligase, associates with Insig-1 and couples sterol-regulated ubiquitination to degradation of HMG CoA reductase.

UniProt record for INSIG2