Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

Presenilin is required for activity and nuclear access of Notch in Drosophila.

aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation.

The role of presenilin cofactors in the gamma-secretase complex.

In vivo reconstitution of gamma-secretase in Drosophila results in substrate specificity.