Gene Ontology annotation through association of InterPro records with GO terms
Use of the ND evidence code for Gene Ontology (GO) terms
Annotation inferences using phylogenetic trees
Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
Combined Automated Annotation using Multiple IEA Methods
Proteomic characterization of the human sperm nucleus.
A Remodeled Hsp90 Molecular Chaperone Ensemble with the Novel Cochaperone Aarsd1 Is Required for Muscle Differentiation.
Cross-editing by a tRNA synthetase allows vertebrates to abundantly express mischargeable tRNA without causing mistranslation.
Eukaryotic AlaX provides multiple checkpoints for quality and quantity of aminoacyl-tRNAs in translation.
UniProt record for AARSD1 (Q9BTE6)
UniProt text export for AARSD1 (Q9BTE6)
Falcon deep research report for AARSD1
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Falcon research supports AARSD1 as a cytoplasmic AlaX trans-editing factor that deacylates serine-mischarged tRNAs to preserve translational fidelity.
"AARSD1/hAlaX is such a free-standing, cytoplasmic trans-editing factor"
OpenScientist hypothesis run: AARSD1 AlaX editing residues vs HSP90
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Confirms AARSD1 is a bona fide AlaX trans-editing deacylase - all four zinc-binding catalytic residues (H109/H113/C209/H213) are present with AlphaFold Zn coordination of 2.0-2.4 Angstroms - and that the HSP90-cochaperone association is a readthrough/fusion-isoform artifact that should not be annotated as an intrinsic AARSD1 function.
"the HSP90 cochaperone association is a readthrough artifact and should not be annotated as an intrinsic function."