Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
AtSubP analysis
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AtSubP predicts cytoplasmic localization for TFL1, consistent with experimental evidence for nucleocytoplasmic shuttling.
"The AtSubP cytoplasm prediction is consistent with direct localization evidence and with TFL1 mobility in meristems."
Effects of sugar on vegetative development and floral transition in Arabidopsis.
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Sucrose can delay floral transition, and low sucrose inhibition was more pronounced in tfl1 mutants, indicating a modifier phenotype rather than a direct TFL1 sucrose-response mechanism.
"This inhibition was more pronounced in tfl1, an early flowering mutant, than in the wild type."
A Mutation in the Arabidopsis TFL1 Gene Affects Inflorescence Meristem Development.
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Loss of TFL1 causes early flowering and terminal floral meristem formation, showing that TFL1 maintains the normally indeterminate inflorescence meristem.
"The tfl1-1 mutation causes early flowering and limits the development of the normally indeterminate inflorescence by promoting the formation of a terminal floral meristem."
TERMINAL FLOWER1 is a mobile signal controlling Arabidopsis architecture.
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TFL1 protein moves from inner meristem cells through the meristem, allowing it to affect cell fates beyond its RNA expression domain.
"We reveal that the TFL1 protein is a mobile signal that becomes evenly distributed across the meristem."
The shoot meristem identity gene TFL1 is involved in flower development and trafficking to the protein storage vacuole.
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TFL1 was identified as a factor required for proper protein storage vacuole trafficking and localizes to endomembrane/AP-3-associated compartments.
"The tfl1-19/mtv5 (for "modified traffic to the vacuole") mutant is specifically defective in trafficking of proteins to the PSV."
Arabidopsis TERMINAL FLOWER1 is involved in the regulation of flowering time and inflorescence development through transcriptional repression.
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TFL1 negatively modulates FD-dependent transcription and thereby regulates flowering time and inflorescence meristem development.
"We conclude that TFL1 negatively modulates the FD-dependent transcription of target genes to fine-tune flowering time and the development of the inflorescence meristem."
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TFL1 interacts with FD in the nucleus and is also detected in the cytoplasm, supporting a nucleocytoplasmic shuttling model.
"We demonstrated interaction between TFL1 and FD in the nucleus by a BiFC assay and showed that the TFL1 protein is present in nucleus and cytoplasm"
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TFL1 is a PEBP/CETS-family protein with FT-like sequence similarity but antagonistic floral regulatory function.
"TFL1 shares 71% similar amino acid residues (including 55% identical residues) with FT."
Genetic interactions reveal the antagonistic roles of FT/TSF and TFL1 in the determination of inflorescence meristem identity in Arabidopsis.
Deep research summary for Arabidopsis TFL1 (Falcon)
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The Falcon research synthesis identifies FD-dependent transcriptional repression and antagonism with FT/TSF as the primary functional model for Arabidopsis TFL1.
"A central experimentally supported model is that TFL1 negatively modulates FD-dependent transcription to repress floral induction/meristem identity programs."
PANTHER family PTHR11362 metadata for phosphatidylethanolamine-binding proteins
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PANTHER classifies the TFL1 family as phosphatidylethanolamine-binding proteins, consistent with the PEBP/CETS family context used in the review.
"PHOSPHATIDYLETHANOLAMINE-BINDING PROTEIN"
PANTHER PTHR11362 reviewed entries including Arabidopsis TFL1 and related PEBPs
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The reviewed PANTHER entries place Arabidopsis TFL1 in subfamily PTHR11362:SF13, separate from Arabidopsis FT/TSF flowering-locus-T-related subfamily entries.
"P93003,Protein TERMINAL FLOWER 1,protein,3702,Arabidopsis thaliana,Arabidopsis thaliana (Mouse-ear cress),TFL1,177,PTHR11362:SF13,PROTEIN TERMINAL FLOWER 1,True"