GO_REF:0000002
Gene Ontology annotation through association of InterPro records with GO terms
GO_REF:0000033
Annotation inferences using phylogenetic trees
GO_REF:0000043
Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
GO_REF:0000052
Gene Ontology annotation based on curation of immunofluorescence data
GO_REF:0000107
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
GO_REF:0000113
Gene Ontology annotation of human sequence-specific DNA binding transcription factors (DbTFs) based on the TFClass database
GO_REF:0000117
Electronic Gene Ontology annotations created by ARBA machine learning models
GO_REF:0000120
Combined Automated Annotation using Multiple IEA Methods
PMID:10698945
Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1.
PMID:12039952
Identification of protein arginine methyltransferase 2 as a coactivator for estrogen receptor alpha.
PMID:1310351
Retinoid X receptor interacts with nuclear receptors in retinoic acid, thyroid hormone and vitamin D3 signalling.
PMID:16189514
Towards a proteome-scale map of the human protein-protein interaction network.
PMID:16417524
Akt phosphorylates and suppresses the transactivation of retinoic acid receptor alpha.
PMID:16456540
P38MAPK-dependent phosphorylation and degradation of SRC-3/AIB1 and RARalpha-mediated transcription.
PMID:16606617
Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor.
PMID:16769902
Phosphorylation by PKA potentiates retinoic acid receptor alpha activity by means of increasing interaction with and phosphorylation by cyclin H/cdk7.
PMID:17363140
The core component of the mammalian SWI/SNF complex SMARCD3/BAF60c is a coactivator for the nuclear retinoic acid receptor.
PMID:17538076
Regulation of 17-beta hydroxysteroid dehydrogenase type 2 in human placental endothelial cells.
PMID:17560333
Role of the polycomb repressive complex 2 in acute promyelocytic leukemia.
PMID:17641689
MED25 is distinct from TRAP220/MED1 in cooperating with CBP for retinoid receptor activation.
PMID:18048326
Identification of retinoic acid as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
PMID:18416830
The Retinoic Acid Receptor-alpha mediates human T-cell activation and Th2 cytokine and chemokine production.
PMID:18845237
Retinoic acid regulates the human methionine sulfoxide reductase A (MSRA) gene via two distinct promoters.
PMID:18922886
Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter.
PMID:19345331
ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome.
PMID:19628791
Induction of transglutaminase 2 by a liver X receptor/retinoic acid receptor alpha pathway increases the clearance of apoptotic cells by human macrophages.
PMID:19850744
Small ubiquitin-like modifier-2 modification of retinoic acid receptor-alpha regulates its subcellular localization and transcriptional activity.
PMID:19917671
Loss of CAK phosphorylation of RAR{alpha} mediates transcriptional control of retinoid-induced cancer cell differentiation.
PMID:19934264
Reciprocal roles of SIRT1 and SKIP in the regulation of RAR activity: implication in the retinoic acid-induced neuronal differentiation of P19 cells.
PMID:20080953
Cooperative interaction between retinoic acid receptor-alpha and estrogen receptor in breast cancer.
PMID:20133701
LIM protein Ajuba functions as a nuclear receptor corepressor and negatively regulates retinoic acid signaling.
PMID:20211142
An atlas of combinatorial transcriptional regulation in mouse and man.
PMID:20215566
Activity of retinoic acid receptor-alpha is directly regulated at its protein kinase A sites in response to follicle-stimulating hormone signaling.
PMID:20413580
Human ADA3 regulates RARalpha transcriptional activity through direct contact between LxxLL motifs and the receptor coactivator pocket.
PMID:20543827
A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.
PMID:21131358
Induction of miR-21 by retinoic acid in estrogen receptor-positive breast carcinoma cells: biological correlates and molecular targets.
PMID:21478865
Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings.
PMID:21516116
Next-generation sequencing to generate interactome datasets.
PMID:21988832
Toward an understanding of the protein interaction network of the human liver.
PMID:22056876
A retinoic acid receptor RARα pool present in membrane lipid rafts forms complexes with G protein αQ to activate p38MAPK.
PMID:22351778
Familial focal segmental glomerulosclerosis (FSGS)-linked α-actinin 4 (ACTN4) protein mutants lose ability to activate transcription by nuclear hormone receptors.
PMID:23518351
The histone demethylase PHF8 governs retinoic acid response in acute promyelocytic leukemia.
PMID:23693014
Activation of Akt pathway by transcription-independent mechanisms of retinoic acid promotes survival and invasion in lung cancer cells.
PMID:24819975
Small ubiquitin-related modifier-1 modification regulates all-trans-retinoic acid-induced differentiation via stabilization of retinoic acid receptor α.
PMID:25036637
A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways.
PMID:25241761
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network.
PMID:25303530
Enhancer activation requires trans-recruitment of a mega transcription factor complex.
PMID:25416956
A proteome-scale map of the human interactome network.
PMID:26871637
Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.
PMID:28122350
Transcriptional suppression of microRNA-27a contributes to laryngeal cancer differentiation via GSK-3β-involved Wnt/β-catenin pathway.
PMID:2825025
A human retinoic acid receptor which belongs to the family of nuclear receptors.
PMID:28473536
Impact of cytosine methylation on DNA binding specificities of human transcription factors.
PMID:29892012
An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders.
PMID:31515488
Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations.
PMID:32296183
A reference map of the human binary protein interactome.
PMID:35512704
Systematic discovery of mutation-directed neo-protein-protein interactions in cancer.
PMID:9430642
The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.
PMID:9628876
Two distinct nuclear receptor interaction domains in NSD1, a novel SET protein that exhibits characteristics of both corepressors and coactivators.
PMID:9653119
The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion.
Reactome:R-HSA-376419
Formation of NR-MED1 Coactivator Complex
Reactome:R-HSA-382096
Formation of NR-NCOR Corepressor Complex
Reactome:R-HSA-4341072
SUMOylation of RARA with SUMO2
Reactome:R-HSA-5334854
RAR:RXR binds SUMO-CRABP2:atRA
Reactome:R-HSA-5634103
SUMO-CRABP2 dissociates from atRA:RAR:RXR
Reactome:R-HSA-9009817
Acitretin binds to RAR:RXR
Reactome:R-HSA-9617067
All-trans retinoic acid binds RARA:RXRA at the promoter of the CEBPE gene
Reactome:R-HSA-9860125
Binding of ATRA to TGFBR3 gene promoter
file:human/RARA/RARA-deep-research-falcon.md
Falcon deep research report on RARA
file:human/RARA/RARA-uniprot.txt
UniProtKB record for RARA