Br140 (Q7JVP4) review notes
- BRPF homolog; scaffold of the Enok complex. PMID:27198229
- Required for H3K23ac. PMID:27198229
- Br140 purifications recovered Elg1 complex subunits. PMID:27198229
- Decisions: shared Enok complex conventions (see enok-notes.md); histone reader IBA accepted at general level (specific marks unknown in fly); transcription/chromatin-remodeling IBAs kept non-core.
Deep research (falcon, added after initial review)
Br140-deep-research-falcon.md agrees: Br140 is the non-catalytic scaffold/regulatory subunit of the Enok complex ["Br140 supports Enok abundance and activity and broadens its substrate specificity in vitro."], supporting the acetyltransferase activator annotation. It also reports embryonic Br140 co-purification with PRC1 and Ash1 and co-binding with Pc at >2,000 genes (Kang 2017, not in GOA), and a PWWP-domain allele with an axon-targeting phenotype; the specific histone marks Br140 reads remain unmeasured. No annotation decisions changed.
PR 4481 review fixes
- Core function now carries GO:0010698 acetyltransferase activator activity as molecular_function alongside contributes_to GO:0043994, with the PMID:27198229 quotes.