Gene Ontology annotation through association of InterPro records with GO terms

Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

Annotation inferences using phylogenetic trees

Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping

Gene Ontology annotation based on curation of immunofluorescence data

Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara

Automatic assignment of GO terms using logical inference, based on inter-ontology links

Electronic Gene Ontology annotations created by ARBA machine learning models

Combined Automated Annotation using Multiple IEA Methods

Dentatorubral-pallidoluysian atrophy protein interacts through a proline-rich region near polyglutamine with the SH3 domain of an insulin receptor tyrosine kinase substrate

Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1

IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling

Cdc42Hs facilitates cytoskeletal reorganization and neurite outgrowth by localizing the 58-kD insulin receptor substrate to filamentous actin

Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex

The insulin receptor substrate IRSp53 links postsynaptic shank1 to the small G-protein cdc42

A novel actin bundling/filopodium-forming domain conserved in insulin receptor tyrosine kinase substrate p53 and missing in metastasis protein

Structural basis of filopodia formation induced by the IRSp53/MIM homology domain of human IRSp53

Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation

E-cadherin interactome complexity and robustness resolved by quantitative proteomics

Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53.

IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness.

Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization.

Towards a proteome-scale map of the human protein-protein interaction network.

A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.

The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation.

Large-scale mapping of human protein-protein interactions by mass spectrometry.

The Cdc42 effector IRSp53 generates filopodia by coupling membrane protrusion with actin dynamics.

Kank attenuates actin remodeling by preventing interaction between IRSp53 and Rac1.

SPIN90-IRSp53 complex participates in Rac-induced membrane ruffling.

Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF).

Regulation of IRSp53-dependent filopodial dynamics by antagonism between 14-3-3 binding and SH3-mediated localization.

A human MAP kinase interactome.

Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization.

Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms.

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells.

A proteome-scale map of the human interactome network.

The EHEC-host interactome reveals novel targets for the translocated intimin receptor.

Phospho-tyrosine dependent protein-protein interaction network.

A human interactome in three quantitative dimensions organized by stoichiometries and abundances.

Architecture of the human interactome defines protein communities and disease networks.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS(G13D).

Dual proteome-scale networks reveal cell-specific remodeling of the human interactome.

OpenCell: Endogenous tagging for the cartography of human cellular organization.

Physical and functional interactome atlas of human receptor tyrosine kinases.

A central chaperone-like role for 14-3-3 proteins in human cells.

Systematic identification of post-transcriptional regulatory modules.

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.

Large-scale proteomics and phosphoproteomics of urinary exosomes.

Missing-in-metastasis and IRSp53 deform PI(4,5)P2-rich membranes by an inverse BAR domain-like mechanism.

A mechanosensing mechanism controls plasma membrane shape homeostasis at the nanoscale.

BIN1 regulates actin-membrane interactions during IRSp53-dependent filopodia formation.

Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases.

Enhanced NMDA receptor-mediated synaptic transmission, enhanced long-term potentiation, and impaired learning and memory in mice lacking IRSp53.

Postsynaptic distribution of IRSp53 in spiny excitatory and inhibitory neurons.

Secretory granules of hypophyseal and pancreatic endocrine cells contain proteins of the neuronal postsynaptic density.

RAC1:GTP and PIP3 bind WAVE Regulatory Complex

(WASPs, WAVE):G-actin:ARP2/3 binds F-actin

p-ERK phosphorylates WAVEs and ABI

ABL phosphorylates WAVEs

Detachment of WASP/WAVE

RAC1 binds effectors at the plasma membrane

CDC42 binds effectors at the plasma membrane

Deep research review of BAIAP2/IRSp53

A lissencephaly-associated BAIAP2 variant causes defects in neuronal migration during brain development.

De novo missense variants in BAIAP2 are associated with developmental and epileptic encephalopathies.