VRN2 curation notes

Session 2026-10-05 (vernalization_flc_silencing module)

• Q8W5B1, At4g16845; Su(z)12 homolog (VEFS box). Falcon deep research failed.
• Maintenance, not initiation: PMID:11719192
• Constitutive association with FLC: PMID:18854416
• In vivo VRN2-PRC2: PMID:26642436
• PHD-PRC2: PMID:18854416.

Decisions

• ISS DNA-binding transcription factor activity (from the Riechmann 2000 TF catalog) -> REMOVE; VRN2 is a PRC2 subunit, not a TF. The IEA regulation of DNA-templated transcription derived from it -> MODIFY to GO:0045814.
• Transcription corepressor binding (IPI with AGAMOUS, PMID:28825728) -> MODIFY to DNA-binding transcription factor binding (GO:0140297); the partner given in GOA is a MADS TF. The full text was not available.
• IBA DNA methylation-dependent constitutive heterochromatin (FIS2 seed) -> MODIFY to facultative heterochromatin formation.
• Seven protein binding rows -> REMOVE (complex membership captured by CC).
• NEW: part_of ESC/E(Z) complex (GO:0035098).
• Core function: contributes_to histone H3K27 methyltransferase activity (catalysed by CLF/SWN).