bfd (PA3530, Q9HY80) review notes
Review session 2026-11-05 (PseudoCAP IBA-seed protocol, tier 2)
Fetched with just fetch-gene PSEAE Q9HY80 --alias bfd; accession matches the worklist.
No deep-research provider used. PMID:17915950 (the only GOA-cited paper) is abstract-only (no PMC
copy). Later Bfd papers (PMID:19575528, 22812654, 26368531, 28318006, 30183257, 35327558) are not
cached; their findings are taken from the curated Swiss-Prot record (ECO:0000269 statements).
Literature
- Bfd is a 73-residue [2Fe-2S] protein PMID:17915950.
- Electron transfer from Bfd to heme oxygenase is sluggish, so FPR, not Bfd, is the HemO partner PMID:17915950.
- Bfd binds bacterioferritin BfrB (up to 12 per 24-mer) and is required for mobilizing Fe from the
BfrB core; mobilization needs the [2Fe-2S] cluster (UniProt CC FUNCTION, PubMed:19575528,
22812654, 26368531, 28318006, 30183257). The bfd mutant accumulates unmobilizable iron in BfrB
under low iron (UniProt CC DISRUPTION PHENOTYPE, PubMed:28318006).
- Induced by iron starvation (PMID:12207696, via UniProt CC INDUCTION).
Annotation decisions
- ACCEPT: GO:0051537 (IDA, IBA).
- No NEW rows proposed. The iron-mobilization role (bacterioferritin iron release, intracellular
iron ion homeostasis) is well supported by later papers but they are not cached here; recorded
for a future pass.
- Action counts: ACCEPT 2. No source defects.
PseudoCAP IBA-seed assessment
| PTN node |
node term |
n_seeds |
leaf IBAs |
seed annotation (term, evidence, PMID) |
verdict |
rationale |
other seeds |
IBD stands without this seed? |
| PTN002205442 |
GO:0051537 2 iron, 2 sulfur cluster binding |
2 |
12 (12 taxa) |
GO:0051537, IDA, PMID:17915950 (PseudoCAP) |
SOUND |
Abstract states outright that Bfd incorporates a [2Fe-2S] centre (spectroscopy); confirmed by later structures. |
E. coli Bfd P0AE56 (IDA PMID:8639572, PMID:8954950) |
Yes |
Node term suits the clade: the 12 leaves are Bfd-family proteins carrying the Fer2_BFD
(BFD-like [2Fe-2S]-binding) domain with its conserved cysteines.